Quantification correction for free-breathing myocardial T_1ρ mapping in mice using a recursively derived description of a T_1ρ* relaxation pathway.

ABSTRACT:

Background

Fast and accurate T_1ρ mapping in myocardium is still a major challenge, particularly in small animal models. The complex sequence design owing to electrocardiogram and respiratory gating leads to quantification errors in in vivo experiments, due to variations of the T_1ρ relaxation pathway. In this study, we present an improved quantification method for T_1ρ using a newly derived formalism of a T_1ρ* relaxation pathway.

Methods

The new signal equation was derived by solving a recursion problem for spin-lock prepared fast gradient echo readouts. Based on Bloch simulations, we compared quantification errors using the common monoexponential model and our corrected model. The method was validated in phantom experiments and test

SUBMITTER: Gram M 

PROVIDER: S-EPMC9082875 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature