Metabolism of oxygen via T₂ and interleaved velocity encoding: A rapid method to quantify whole-brain cerebral metabolic rate of oxygen.

ABSTRACT:

Purpose

Cerebral metabolic rate of oxygen (CMRO₂ ) is an important biomarker of brain function. Key physiological parameters required to quantify CMRO₂ include blood flow rate in the feeding arteries and venous oxygen saturation (SvO₂ ) in the draining vein. Here, a pulse sequence, metabolism of oxygen via T₂ and interleaved velocity encoding (MOTIVE), was developed to measure both parameters simultaneously and enable CMRO₂ quantification in a single pass.

Methods

The MOTIVE sequence interleaves a phase-contrast module between a nonselective saturation and a background-suppressed T₂ -prepared EPI readout (BGS-EPI) to measure T₂ of blood water protons and cerebral blood flow in 20 s or less. The MOTI

SUBMITTER: Deshpande RS 

PROVIDER: S-EPMC9247043 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature