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ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
Proteomicsabdominal aortic aneurysm (AAA) proteomics
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD067859 | Pride
Dia-ms Human tissue Abdominal aortic aneurysm 
TranscriptomicsMicroRNA profiling of cells isolated from human abdominal aortic aneurysms. Let-7f, a new potential circulating biomarker
This study aims to identify and characterize miRNA expression in aneurysmal smooth muscle cells (SMCs) and M1 and M2 macrophages isolated by laser microdissection from human AAA biopsy samples. The aim of this study was to profile (with microarray technology) miRNAs in M1 and M2 macrophages and Smoo...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-62179 | biostudies-arrayexpress
TranscriptomicsGene expression study in Positron Emission Tomography (PET) positive abdominal aortic aneurysms
This study aims at identifying genes involved in this metabolic activation potentially related to rupture. A genome-wide transcriptomic analysis was performed on biopsies collected from patients with a Fluorodeoxyglucose (FDG) uptake both in the positive spot (A+Pos) and in a distant negative site o...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-MTAB-3175 | biostudies-arrayexpress
ProteomicsCycloastragenol inhibit experimental abdominal aortic aneurysm progression
Abstract: The pathogenesis of AAA involves vascular inflammation and oxidative stress. Astragali Radix contains cycloastragenol (CAG) known to have anti-inflammatory and anti-oxidative properties. We hypothesized that CAG supplement impairs AAA progression. AAA was induced in male rats by intralumi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD030441 | Pride
Aortic aneurysm  pathogenesis  pharmacological therapy  experimental model  drug delivery 
ProteomicsIdentification of potential plasma biomarkers for abdominal aortic aneurysm using tandem mass tag quantitative proteomics
Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative prot...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD011309 | Pride
Plasma proteomics  immunodepletion  tandem mass tags  tmt  abdominal aortic aneurysm  cardiovascular diseases 
ProteomicsMouse and human abdominal aneurysm proteomics
Aortic tissues of developing and established aneurysms produced by angiotensin II (AngII) infusion were examined in Apoe-/- and Ldlr-/- mice. Aortas were also acquired from wildtype C57BL/6J mice following intraluminal elastase incubation. Aortas were dissected free and separated into eight anatom...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-02 | PXD032293 | Pride
Fermt3 Co-regulation Mass spectrometry 
ProteomicsNicotine administration augments abdominal aortic aneurysm progression in rats
Inflammation and elastin degradation are key hallmarks in the pathogenesis of abdominal aortic aneurysms (AAA). It has been acknowledged that activation of alpha7 nicotinic acetylcholine receptors (α7nAChRs) attenuates inflammation, termed the cholinergic anti-inflammatory pathway (CAP). Thus, we hy...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040414 | Pride
Therapeutic strategy Inflammation Aortic aneurysm Proteomics Alpha7 nicotinic acetylcholine receptor Vascular remodeling Nicotine Animal model 
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