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ProteomicsASSESSING AUTOMATED SAMPLE PREPARATION TECHNOLOGIES FOR HIGH-THROUGHPUT PROTEOMICS OF FROZEN WELL CHARACTERIZED TISSUES FROM SWEDISH BIOBANKS
Large cohorts of carefully collected and stored clinical tissue materials play a central role in acquiring sufficient depth and statistical power to discover disease-related mechanisms and biomarkers of clinical significance. Manual preparation of such heterogeneous samples is labor intensive and re...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-11-27 | PXD010296 | Pride
Bravo assaymap Tissue Mass spectrometry Clinical proteomics Barocycler Bioruptor 
ProteomicsAUTOMATED PHOSPHOPEPTIDE ENRICHMENT FROM MINUTE QUANTITIES OF FROZEN MALIGNANT MELANOMA TISSUE
To acquire a deeper understanding of malignant melanoma (MM), it is essential to study the proteome of patient tissues. In particular, phosphoproteomics of MM has become of significant importance because of the central role that phosphorylation plays in the development of MM. Investigating clinical ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD011175 | Pride
Bravo assaymap Sensitivity Fe(iii)-imac. Malignant melanoma phosphoproteomics Phosphopeptide enrichment 
ProteomicsRobust, sensitive and automated phosphopeptide enrichment optimized for low sample amounts applied to primary hippocampal neurons
Due to the low stoichiometry of protein phosphorylation, targeted enrichment prior to LC-MS/MS analysis is still essential. The trend in phosphoproteome analysis is shifting towards an increasing number of biological replicates per experiment, ideally starting from very low sample amounts, placing n...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2016-12-14 | PXD005366 | Pride
Phosphoproteomics  quantification  fe(iii)-imac  ti(iv)-imac  tio2  bravo assaymap  phosphopeptide enrichment  sensitivity  egf  hippocampal neurons 
ProteomicsASSESSING AUTOMATED SAMPLE PREPARATION TECHNOLOGIES FOR HIGH-THROUGHPUT PROTEOMICS OF FROZEN WELL CHARACTERIZED TISSUES FROM SWEDISH BIOBANKS
Large cohorts of carefully collected and stored clinical tissue materials play a central role in acquiring sufficient depth and statistical power to discover disease-related mechanisms and biomarkers of clinical significance. Manual preparation of such heterogeneous samples is labor intensive and re...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-11-27 | PXD011295 | Pride
Mass spectrometry clinical peoteomics 
ProteomicsAutomated Phosphopeptide Enrichment for Gram Positive Bacteria
Protein phosphorylation in prokaryotes has gained more attention in recent years as several studies linked it to regulatory and signalling functions indicating an importance similar to protein phosphorylation in eukaryotes. Studies on bacterial phosphorylation have so far been conducted using manual...
ORGANISM(S): Listeria monocytogenes EGD 
2021-08-26 | PXD025459 | Pride
Bravo assaymap  fe(iii)-imac  tio2  automation  phosphopeptide enrichment  phosphoproteomics  quantification  listeria monocytogenes  bacillus subtilis  streptococcus pyogenes 
UnknownHarnessing New Tools for Old Challenges: Optimising Neat Plasma Proteomics with Automation and Gas-Phase Fractionation.
Not available
S-EPMC12921592 | biostudies-literature
UnknownAnalytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab.
Not available
S-EPMC12296118 | biostudies-literature
UnknownAutomated phosphopeptide enrichment from minute quantities of frozen malignant melanoma tissue.
Not available
S-EPMC6287822 | biostudies-literature
ProteomicsHeLa Pro-IL-1a TurboID LC-MS/MS
Pro-IL-1a is a pro-inflammatory cytokine that is localised to the nucleus in humans due to the presence of a nuclear localisation sequence in its pro-domain. However, some mammals have a predicted loss of fucntion to their nuclear localistion sequence. It is suggested that pro-IL-1a serves as a dual...
ORGANISM(S): Homo sapiens (Human) 
2024-06-28 | PXD053438 | Pride
Inflammation Turboid Biotin ligase proximity labelling Pro-interleukin-1 alpha Histone acetyl transferase Lc-ms/ms 
ProteomicsFrizzled4 proximity interactors
Frizzled4 (FZD4) is a pivotal receptor for Norrin and Wnt7a/b that mediates CNS angiogenesis, blood-brain barrier function and blood-retina barrier function. FZD4 is a target for pharmacological interventions in retinal and neurological disease. In order to understand mechanisms of regulation of Fri...
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD065058 | Pride
Fzd4 Hela Hek293t Bioid Lc-ms/ms 
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