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ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
ProteomicsSystematic Evaluation and Optimization of Protein Extraction Parameters in Diagnostic FFPE Specimens
Objectives: Formalin-fixed paraffin-embedded (FFPE) tissue is the standard material for di-agnostic pathology but poses relevant hurdles to accurate protein extraction due to cross-linking and chemical alterations. While numerous extraction pro-tocols and chemicals have been described, systematic c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029133 | Pride
Protein extraction  formalin-fixed paraffin-embedded tissue  clinical prote-omics  antigen retrieval  crosslinking reversal  protein analysis  biomarker 
MetabolomicsFinger sweat analysis enables short interval metabolic biomonitoring in humans

Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues and are impractical for performing time-course studies. The analysis of ...

2021-08-13 | MTBLS2776 | MetaboLights
MetabolomicsFinger sweat analysis enables short interval metabolic biomonitoring in humans

Metabolic biomonitoring in humans is typically based on the sampling of blood, plasma or urine. Although established in the clinical routine, these sampling procedures are often associated with a variety of compliance issues and are impractical for performing time-course studies. The analysis of ...

2021-08-13 | MTBLS2772 | MetaboLights
ProteomicsPathology-driven epithelial sulfide loss reprograms the redox proteome and triggers Barrett’s esophagus
Background & AimsBarrett’s esophagus (BE), a metaplastic transformation driven by gastroesophageal reflux disease (GERD), induces oxidative stress but the underlying redox mechanisms remain poorly understood. Protein persulfidation (PSSH), a redox-sensitive, reversible, and antioxidative post-transl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD047338 | Pride
Persulfidation  hydrogen sulfide  barrett’s esophagus  gastroesophageal reflux disease (gerd)  prostaglandin e2/interleukin 1/mtor cross-talk 
ProteomicsTWIST1 expression is associated with high-risk Neuroblastoma and promotes Primary and Metastatic Tumor Growth
In this study, merging in silico transcriptomic data and in situ TMA studies, we first highlighted the clinical significance and the value as prognostic factors of the embryonic TFs TWIST1 and TWIST2, thus linking their level of expression with the outcome of NB patients. Secondly, using NB cells k...
ORGANISM(S): Homo sapiens (Human) 
2022-01-10 | PXD024200 | Pride
Neuroblastoma Myofibroblasts Twist1/2 Tumor-stroma cross-talk Metastasis Tumor microenvironment Secretome Extracellular matrix 
ProteomicsChemical phosphoproteomics sheds new light on the targets and modes of action of AKT inhibitors
Due to its important roles in oncogenic signaling, AKT has been subject to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials. To better understand how these drugs exert their therapeutic effects at the molecular level, we combined chemopro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD021836 | Pride
Kinobeads Akt inhibitor Phosphoproteomics 
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