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MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
ProteomicsThe mammalian longevity associated acetylome
Despite extensive studies at the genomic, transcriptomic and metabolomic levels, the underlying mechanisms regulating longevity are incompletely understood. Post-translational protein acetylation is suggested to regulate aspects of longevity. To further explore the role of acetylation, we develop th...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-30 | PXD061654 | Pride
Acetylome Longevity Pharaoh 
TranscriptomicsGenetic analysis reveals a longevity associated protein modulating endothelial function and angiogenesis
Transcriptome analysis in HEK293T transfected with plasmid carrying different isoforms of BPIFB4 gene. This gene was previously associated with exceptional longevity in a GWAS study performed on three different populations. Results indicate an up-regulation of stress response genes and proteostasis ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-63912 | biostudies-arrayexpress
ProteomicsBarley seed proteome analysis - Genes for seed longevity in barley identified by genomic analysis on near isogenic lines
Genes controlling differences in seed longevity between two barley (Hordeum vulgare) accessions were identified by combining a quantitative genetics approach with ˈomicsˈ technologies in Near Isogenic Lines (NILs). The NILs were derived from crosses between the spring barley landraces L94 from Ethio...
ORGANISM(S): Hordeum vulgare (Barley) 
2018-07-23 | PXD009464 | Pride
Longevity Seed Barley Label-free quantification 
ProteomicsSpecies comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
Mammals display wide range of variation in their lifespan. Investigating the molecular networks that distinguish long- from short-lived species has proven useful to identify determinants of longevity. Here, we compared the liver of long-lived naked mole-rats (NMRs) and the phylogenetically closely r...
ORGANISM(S): Homo sapiens (Human) Heterocephalus glaber Cavia porcellus (Guinea pig) 
2018-06-21 | PXD008720 | Pride
Naked mole-rat Liver Longevity Human aging 
ProteomicsA TMT- based comparative quantitative proteomics analysis was used to reveal the changes of plasma proteomics profiles between longevity subjects and non-longevity area participants in order to identify plasma proteins associated with glucose metabolism in longevity population
High blood glucose level is one of the main characteristics of diabetes mellitus (DM). It is speculated that longevity families may have certain advantages in blood glucose regulation. But till now, limited information on these items is reported. In this study, a TMT- based comparative quantitative ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032932 | Pride
Human plasma lc/msms tmt 
UnknownDeficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Not available
S-EPMC3292902 | biostudies-literature
UnknownDeveloping Enzyme Immobilization with Fibrous Membranes: Longevity and Characterization Considerations.
Not available
S-EPMC10221158 | biostudies-literature
TranscriptomicsIntestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
We identified that Drosophila FoxA transcription Fork Head (FKH) function is necessary for reduced insulin signalling and rapamycin induced longevity. Furthermore, we determined that FKH function in the gut tissue alone is sufficient to extend lifespan. We carried out RNA-sequencing in gut tissue o...
ORGANISM(S): Drosophila melanogaster 
2017-09-23 | E-MTAB-6056 | biostudies-arrayexpress
ProteomicsHSF-1 promotes longevity through ubiquilin-1 dependent mitochondrial remodelling
Impaired protein homeostasis promotes age-associated tissue dysregulation, presenting a need for therapeutic approaches that can restore proteome integrity. The heat shock factor HSF-1 is the master transcriptional regulator of proteostasis and regulates the expression of heat shock proteins (HSPs),...
ORGANISM(S): Caenorhabditis elegans 
2024-10-17 | PXD044595 | Pride
Hsf-1  aging  proteomics 
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