epidermal differentiation

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Unknown (2145)
Transcriptomics (1551)
Genomics (841)
Proteomics (85)
Other (21)
Metabolomics (9)
Models (8)
Methylation profiling (7)
Genomic (1)

Organisms

Homo sapiens (969)
Mus musculus (602)
Arabidopsis thaliana (48)
Rattus norvegicus (22)
Drosophila melanogaster (17)
Xenopus laevis (12)
Gallus gallus (8)
Danio rerio (6)
Caenorhabditis elegans (4)
Oryza sativa (4)
Rhodospirillum rubrum (3)
Callithrix jacchus (3)
Bos taurus (3)
Glycine max (3)
Gossypium hirsutum (3)
Sus scrofa (3)
Macaca mulatta (2)
Hordeum vulgare (2)
Salmo salar (2)
Oryctolagus cuniculus (2)
cellular organisms (1)
Mammalia (1)
Pseudomonas aeruginosa PAHM4 (1)
Mus sp. (1)
Rana pirica (1)
uncultured bacterium (1)
Papio anubis (1)
Cannabis sativa (1)
Macaca fascicularis (1)
Apis mellifera (1)

Organisms

Homo sapiens (337)
Mus musculus (214)
Arabidopsis thaliana (17)
Schmidtea mediterranea (10)
Xenopus laevis (9)
Drosophila melanogaster (8)
Xenopus tropicalis (4)
Rattus norvegicus (4)
Gallus gallus (4)
Danio rerio (3)
Oryza sativa (2)
Hemiphyllodactylus yunnanensis (1)
Pogostemon cablin (1)
Populus tremula x Populus alba (1)
Gossypium arboreum (1)
Bos grunniens (1)
Hydra vulgaris (1)
Rorippa aquatica (1)
Ambystoma mexicanum (1)
Oikopleura dioica (1)
Caenorhabditis elegans (1)
Ovis aries (1)
Canis lupus familiaris (1)
Sus scrofa (1)
Gossypium hirsutum (1)

Repository

biostudies-arrayexpress (1139)
ENA (684)
geo (594)
pride (34)
MassIVE (29)
EGA (9)
jPOST (8)
MetaboLights (8)
BioModels (4)
Cell Collective (4)
PanoramaPublic (4)
PAXDB (4)
LINCS (3)
iProX (2)
ExpressionAtlas (1)
dbGaP (1)
GPMDB (1)
MetabolomicsWorkbench (1)

Tissue

Keratinocyte (14)
Skin (14)
Cell culture (6)
Epithelial cell (4)
Claw (2)
Neuroblastoma cell line (2)
Brain (2)
Stem cell (2)
Sweat (1)
Ganglioneuroma cell (1)
Neuroblastoma cell (1)
Nerve (1)
Skin fibroblast (1)
Epidermal keratinocyte (1)
Epithelial cell of lung (1)
Schwann cell (1)
Neuronal stem cell (1)
Plant cell (1)
Blood plasma (1)
Whole body (1)
Leaf (1)
Primary cell (1)
Permanent cell line cell (1)
Kidney (1)
Blood cell (1)

Disease

Normal (5)
Glioblastoma (4)
Atopic dermatitis (3)
Alopecia (1)
Psoriasis vulgaris (1)
Uninfected 11dpi (1)
Basal cell carcinoma, Gorlin-Goltz syndrome (1)
Glioblastoma multiforme (1)
Tumor (1)
Astrocytoma III (1)
Adenocarcinoma (1)
Breast carcinoma (1)
Neurofibromatosis type 1 (1)
Invasive ductal carcinoma (1)
Breast cancer (1)
Not Available (1)
Psoriasis (1)
Hypersensitivity reaction type I disease (1)
Non-small cell lung carcinoma (1)
Prostate cancer (1)
Neuroblastoma (1)
Cervix carcinoma (1)
Wounds and Injuries (1)
Disease free (1)

Technology Type

Mass Spectrometry (35)
Shotgun proteomics (18)
Bottom-up proteomics (7)
Mass spectrometry (5)
Affinity purification coupled with mass spectrometry proteomics (5)
Gel-based experiment (4)
Mass spectrometry assay (3)
Data-independent acquisition (3)
SRM/MRM (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Illumina HiSeq 4000, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500 (1)
ESI (1)
All-ion fragmentation (1)
HDMSE (1)
Data-dependent acquisition (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (41)
Illumina HiSeq 2500 (20)
NextSeq 500 (17)
Q Exactive (16)
Illumina HiSeq 2000 (15)
Illumina HiSeq 4000 (11)
Illumina Genome Analyzer II (4)
Q Exactive Plus (4)
Illumina HiSeq 3000 (3)
Orbitrap Exploris 480 (3)
Illumina Genome Analyzer IIx (2)
NextSeq 550 (2)
LTQ Orbitrap Elite (2)
10x chromium (1)
G2565BA DNA microarray scanner (1)
G2505. Agilent’s Scan Control software v. A.7.01 and Feature Extraction. (1)
Affymetrix GeneChip Scanner 3000 (GCS3000) (1)
AffymetrixMouse Gene 1.0 ST Array (1)
Illumina BeadArray Reader (1)
AB SOLiD 4 System (1)
G2500A Hewlett Packard (1)
ArrayWoRx Biochip Reader [Applied Precision] (1)
G2565BA DNA microarray scanner [Agilent] (1)
NextSeq 1000 (1)
Illumina NovaSeq X (1)
Illumina HiSeq X (1)
Illumina NextSeq 500 (1)
Illumina MiSeq (1)
Illumina HiSeq 1500 (1)
Instrument (1)

Publication Date

2015 (178)
2013 (155)
2012 (155)
2014 (138)
2010 (128)
2011 (115)
2016 (101)
2024 (82)
2023 (82)
2021 (76)
2009 (75)
2020 (70)
2008 (69)
2026 (63)
2022 (63)
2025 (58)
2018 (54)
2017 (52)
2019 (42)
2007 (40)
2006 (16)
2005 (15)
2004 (1)
2002 (1)

UNIPROT ID/AC

Q9Z1I1 (2)
Q9QX70 (2)
P07522 (2)
P08646 (1)
Q504U8 (1)
P61981 (1)
P62714 (1)
P30086 (1)
Q5M824 (1)
P62994 (1)
P24135 (1)
P10686 (1)
P17252 (1)
P01133 (1)
P47736 (1)
Q62636 (1)
P10113 (1)
Q9QYV3 (1)
P47196 (1)
P47197 (1)
P63086 (1)
P21708 (1)
P36506 (1)
Q01986 (1)
Q99MC6 (1)
P11345 (1)
P50904 (1)
Q9Z1I2 (1)
Q63531 (1)
P35739 (1)

ENSEMBL ID

ENSRNOP00000009359 (1)

CHEBI ID

CHEBI:17750 (3)
CHEBI:17964 (3)
CHEBI:30887 (3)
CHEBI:16027 (3)
CHEBI:1606 (2)
CHEBI:42504 (2)
CHEBI:70958 (2)
CHEBI:17992 (2)
CHEBI:20794 (2)
CHEBI:16192 (2)
CHEBI:17172 (2)
CHEBI:73688 (2)
CHEBI:33508 (2)
CHEBI:16450 (2)
CHEBI:41321 (2)
CHEBI:15350 (2)
CHEBI:17622 (2)
CHEBI:18049 (2)
CHEBI:71465 (2)
CHEBI:75145 (2)
CHEBI:17822 (2)
CHEBI:15611 (2)
CHEBI:16680 (2)
CHEBI:26271 (2)
CHEBI:17287 (2)
CHEBI:18132 (2)
CHEBI:25094 (2)
CHEBI:114785 (1)
CHEBI:15996 (1)
CHEBI:17552 (1)

Metabolite Name

Creatinine (3)
Lactate (2)
Clomipramine (2)
Nicotinamide ribotide (2)
Niacinamide (2)
N6-Acetyl-L-lysine (2)
Kynurenine (2)
Acetylcarnitine (2)
Arginine (2)
Oleamide (2)
Alanine (2)
Phosphorylcholine (2)
Phosphocreatine (2)
Alpha,alpha-Trehalose (2)
Glutamic acid (2)
Urea (2)
Creatine (2)
Glycerophosphocholine (2)
Hypoxanthine (2)
Thr-Pro-Arg (1)
Thr-Gly-Arg (1)
Ser-Asp-Arg (1)
Pyroglu-Asn-Arg (1)
L-valine, n-[[1-(5-fluoropentyl)-1h-indol-3-yl]carbonyl]-, methyl ester (1)
Cys-His-Arg (1)
5-methoxy-4-methyl-3-phenylcoumarin (1)
4-phenylbutan-2-ol (1)
3-quinolinecarboxamide, 1,4-dihydro-8-methoxy-4-oxo-1-pentyl-n-tricyclo[3.3.1.13,7]dec-1-yl- (1)
2-methyl-6(s)-(3-pyridyl)tetrahydro-1,2-oxazine (1)
2-furancarboxylic acid, 5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]- (1)

First Public Date

2014 (128)
2024 (79)
2023 (71)
2026 (59)
2020 (52)
2021 (51)
2025 (50)
2022 (38)
2017 (34)
2015 (34)
2019 (33)
2018 (29)
2016 (17)
2013 (9)

Modelling Approach

Ordinary differential equation model (3)

Lab affiliation

CECS, I-STEM AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, 91100 Corbeil-Essonnes, France (1)
Department of Dermatology Johns Hopkins School of Medicine (1)
1) Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA 2) Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA 3) Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA (1)
Department for Dermatology Medical University of Vienna Währinger Gürtel 18-20, 1090 Vienna (1)
Center for Experimental BioInformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark (1)
Epithelial Systems Biology Laboratory National Heart, Lung, and Blood Institute National Institutes of Health (1)
Medical University of Vienna Department of Dermatology (1)
Oak Ridge National Laboratory, Chemical Sciences Division (1)
Professor of Systems Pharmacology Head of Harvard Program in Therapeutic Science Harvard Medical School (1)
Head of laboratory of Neuro-Oncology, Neurology, ErasmusMC, Rotterdam, The Netherlands (1)
Head of Laboratory of Neuro-Oncology, Erasmus MC, Rotterdam (1)
University of Kiel Institute of Biochemistry Unit for Degradomics of the Protease Web Otto-Hahn-Platz 9 24118 Kiel Germany (1)
Technical University of Denmark, Department of Biotechnology and Biomedicine ETH Zurich, Department of Biology (1)
Utrecht University / Pharmaceutical Sciences Biomolecular Mass Spectrometry and Proteomics Padualaan 8 , 3584 CH Utrecht (1)
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" (1)
University of Vienna, Department of Analytical Chemistry, Joint Metabolome Facility (1)
Ben May Department for Cancer Research, the University of Chicago, Chicago, IL 60637, USA. (1)
UDEAR,INSERM U1056,University of Toulouse III,UPS,Toulouse,France (1)
Institute of Molecular and Cell Biology, University of Tartu, Riia 23b, 51010, Tartu, Estonia (1)
Dept. of Cell & Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA (1)
Max Planck Institute for Molecular Biomedicine Bioanalytical Mass Spectrometry Röntgenstr. 20 48159 Münster Germany (1)
Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, China (1)
Institute of Molecular Health Sciences, Department of Biology, ETH Zurich (1)
Department of Chemistry, University of California Riverside (1)
BK21 Plus KNU Multi-Omics-based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea (1)
Stanford (1)
Institute of Molecular Medicine and Cell Research University of Freiburg Stefan Meier Strasse 17 79104 Freiburg, Germany (1)
Institute for Immunology University Medical Center of the Johannes Gutenberg-University Mainz 55131 Mainz, Germany (1)
Section for Protein Science and Biotherapeutics, Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800, Kongens Lyngby, Denmark (1)
Institute of Organic Chemistry and Biochemistry, Czech Academy of Science, Flemingovo n. 2, Prague, 166 10, Czech Republic (1)

IsPrivate

False (4)

Model Flag

Non Kinetic (1)

Study type

Transcription profiling by array (778)
RNA-seq of coding RNA (119)
ChIP-seq (60)
RNA-seq of coding RNA from single cells (25)
Methylation profiling by array (19)
Comparative genomic hybridization by array (16)
RNA-seq of non coding RNA (15)
Unknown experiment type (13)
Other (12)
ChIP-chip by tiling array (10)
RNA-seq of total RNA (8)
ChIP-chip by array (6)
DNA-seq (6)
Cell line - High-throughput sequencing (5)
Genotyping by array (5)
Cell line - One-color microarray (4)
Transcription profiling by RT-PCR (4)
MicroRNA profiling by array (4)
Proteomic profiling by array (4)
Methylation profiling by high throughput sequencing (3)
Transcription profiling by SAGE (2)
Cell line - Single-cell sequencing (2)
Transcription profiling by tiling array (2)
Hi-C (2)
RNA-seq of non coding RNA from single cells (1)
Animal - One-color microarray (1)
One-color microarray (1)
High-throughput sequencing (1)
Human - One-color microarray (1)
MicroRNA profiling by high throughput sequencing (1)

Release Date

2015 (255)
2021 (223)
2014 (214)
2013 (203)
2012 (194)
2022 (193)
2016 (182)
2019 (173)
2023 (170)
2020 (170)
2011 (166)
2010 (162)
2025 (154)
2017 (151)
2018 (149)
2024 (140)
2009 (103)
2008 (102)
2007 (57)
2026 (32)
2006 (25)
2005 (23)
2004 (9)
2002 (9)
2003 (8)
2001 (4)
2000 (4)
1998 (2)
1997 (2)

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Key roles for SRF in embryonic epidermal differentiation

During development, a polarized sheet of epidermal cells undergoes stratification and differentiation to produce the skin barrier. Through mechanisms poorly understood, the process involves adhesion and Notch signaling. To elucidate how epidermal embryogenesis is governed, we conditionally targeted ...

ORGANISM(S): Mus musculus

2011-01-20 | E-GEOD-25548 | biostudies-arrayexpress

Epidermal differentiation: basal vs. suprabasal keratinocytes

In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...

ORGANISM(S): Homo sapiens

2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress

Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis

Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphoryled by the actions of two S1P-specific phosphatases, sphingosine 1-phosphate phosphatase 1 and 2. To identify the physiologic functions of S1P p...

ORGANISM(S): Mus musculus

2013-08-09 | E-GEOD-40368 | biostudies-arrayexpress

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα

Progenitor cells at the basal layer of skin epidermis play an essential role in maintaining tissue homeostasis and enhancing wound repair in skin. The proliferation, differentiation, and cell death of epidermal progenitor cells have to be delicately regulated, as deregulation of this process can lea...

ORGANISM(S): Homo sapiens (Human)

2020-05-13 | PXD015673 | Pride

Expression data from normal human epidermal keratinocytes undergoing density-induced differentiation and treated with EGF

Combining genome-wide microarray and functional analyses, we found that EGFR activation abrogates barrier function, increasing transepidermal water loss (TEWL) and transepithelial permeability of water-soluble ions and higher molecular weight dextrans, in part by disrupting the expression of tight j...

ORGANISM(S): Homo sapiens

2012-05-02 | E-GEOD-32217 | biostudies-arrayexpress

Diverse epigenetic strategies interact to control epidermal differentiation

This SuperSeries is composed of the following subset Series: GSE34556: Diverse epigenetic strategies interact to control epidermal differentiation [ChIP-Seq] GSE34557: Diverse epigenetic strategies interact to control epidermal differentiation [Illumina bead array] Refer to individual Series

ORGANISM(S): Homo sapiens

2012-06-23 | E-GEOD-34558 | biostudies-arrayexpress

Transcription profiling of human keratinocytes used in a small molecule screen to identify inducers of epidermal keratinocyte differentiation

An essential function of the human epidermis is the maintenance of a protective barrier against the environment. As a consequence, keratinocytes, which make up this layer of the skin, undergo an elaborate process of self-renewal, terminal differentiation and cell death. Misregulation of these proces...

ORGANISM(S): Homo sapiens

2009-04-10 | E-GEOD-6932 | biostudies-arrayexpress

The effects of UVB and the organic osmolyte betaine on rat epidermal keratinocytes in an organotypic culture system

Betaine (trimethylglycine) is a non-toxic, highly water-soluble organic osmolyte widely used in skin care due to its assumed moisturizing and protective properties, but only few studies have addressed its specific effects in skin. Here, the cellular and molecular targets of betaine were analyzed by ...

ORGANISM(S): Rattus norvegicus

2015-10-26 | E-GEOD-63004 | biostudies-arrayexpress

Glucose dissociates DDX21 dimers to regulate mRNA splicing and promote epidermal differentiation

We discovered that glucose directly bind to DDX21, induced the conformation change of the proteins and inhibit its helicase activity. Glucose also inhibits the dimerization of DDX21, re-localize DDX21 from nucleolus to nucleoplasm and reassemble DDX21 to RNA splicing complex. DDX21 is essential for ...

ORGANISM(S): Homo sapiens (Human)

2023-01-05 | PXD028561 | Pride

Proximity labeling Ddx21 Splicing Glucose Bioid Epidermal differentiation

Gene expression signature of the three major epidermal differentiation compartments: interfollicular epidermis (IFE), hair follicle (HF) and sebaceous gland (SG).

There are multiple stem cells in adult mammalian epidermis, but the mechanisms controlling lineage specification are poorly understood. To identify gene expression signatures of the three major epidermal differentiation compartments we micro-dissected individual SG, IFE and HF from adult epidermis. ...

ORGANISM(S): Mus musculus

2017-05-16 | E-GEOD-62604 | biostudies-arrayexpress

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