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The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin. The cancer-specific form osteopontin-c supports anchorage-independence through inducing oxidoreductases a...
ORGANISM(S): Homo sapiens 
Lactoferrin (LF) and osteopontin (OPN) are key bioactive milk proteins with significant immune-modulatory, gut, and systemic health benefits. Using a microarrayed high-throughput 3D intestinal organoid platform, we evaluated the bioavailability and uptake of bovine LF-OPN soluble complexes (SC) and ...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-07-10 | PXD064048 | Pride
Role of osteopontin in the progression of malignant pleural mesothelioma
Protective Role of Macrophage Osteopontin in NASH
The pathogenesis of intestinal fibrosis in Crohn’s disease (CD) remains unclear. Mer receptor tyrosine kinase (MerTK) is an immunosuppressive protein specifically expressed in macrophages. Osteopontin (OPN), also known as secreted phosphoprotein 1, contributes to inflammation and wound repair. This ...
ORGANISM(S): Mus Musculus 
Expression data from hair follicles treated with an osteopontin-derived peptide
Rationale: The role of club cells in the pathology of Idiopathic Pulmonary Fibrosis IPF is not well understood. PDIA3, an endoplasmic reticulum (ER) based redox chaperone catalyzes the cysteine disulfide bonds (-S-S-) in various fibrosis-related proteins; however, mechanisms of action of PDIA3 in pu...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD021715 | Pride
Osteopontin tranfected vs empty vector breast cell line Keywords: parallel sample
ORGANISM(S): Homo sapiens 
2004-01-07 | GSE939 | GEO
Snai2 maintains bone marrow niche cells by repressing osteopontin expression
RNA Sequencing Gene Expression Profile of IEL Incubated In The Presence or Absence of Osteopontin
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