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MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
ProteomicspH dependence of succinimide ester-based protein cross-linking for structural mass spectrometry applications
The pH dependency of the reaction of the cross-linking reagent, disuccinimidyl suberate (DSS), was studied on a set of eight model proteins.
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus (Rabbit) Gallus gallus (Chicken) 
2021-11-15 | PXD027891 | Pride
Chemical cross-linking  dss  model proteins  method optimization  ph dependency 
UnknownOrigin of the pH Dependency of EPR Parameters: The Case of a Protonatable Nitroxide in Aqueous Solution.
Not available
S-EPMC12359196 | biostudies-literature
UnknownSingle Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Not available
S-EPMC8297725 | biostudies-literature
ProteomicsTargetable leukemia dependency on noncanonical PI3Kγ signaling
Phosphoinositide 3-kinase gamma (PI3Kγ) is implicated as a target to repolarize tumor-associated macrophages and promote anti-tumor immune responses in solid cancers. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening wi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-19 | PXD045702 | Pride
Leukemia Cancer Tmt Pi3kγ Pik3r5 Phosphoproteomics 
UnknownInorganic carbon and pH dependency of photosynthetic rates in Trichodesmium.
Not available
S-EPMC6022602 | biostudies-literature
ProteomicsMYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma
Multiple myeloma is an incurable hematological malignancy evolving from precursor states to advanced phases of the disease. MYC abnormalities play a critical role in the disease progression. Nevertheless, MYC lacks therapeutic drugability, thereby necessitating the exploration of alternative strateg...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050010 | Pride
Tmt spectrometry Myc U266 Gls1 Nampt Gene dependency Myc overexpression Cellular metabolism Multiple myeloma 
ProteomicsLocalisation of the Golgi pH regulator GPR89 extends to the endoplasmic reticulum and confers selective dependency in breast cancer
Identification of targetable biology in breast cancer is an important unmet need, particularly for triple negative breast cancer (TNBC) where outcomes are poor and there are few licensed targeted therapies. Here, we identify the anion channel GPR89 as a novel breast cancer oncogene relevant in TNBC ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD031422 | Pride
Gpr89 Triple negative breast cancer Er stress Ire1a 
ProteomicsAssigning functionality to cysteines by base editing of cancer dependency genes
Chemical probes are lacking for most human proteins. Covalent chemistry represents an attractive strategy for expanding the ligandability of the proteome, and chemical proteomics has revealed numerous electrophile-reactive cysteines on diverse proteins. Determining which of these covalent binding ev...
ORGANISM(S): Homo sapiens (Human) 
2023-09-06 | PXD038239 | Pride
Cysteine Base editing Electrophile Cancer dependency Ligandability 
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