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TranscriptomicsEffects of PGRMC1 phosphorylation on genome integrity and epigenetics
Progesterone receptor membrane component 1 (PGRMC1) is a protein that has been implicated in cancer biology and poor patient outcomes, which can be over-expressed in cancers, and exist in alternative states of phosphorylation.Here, we show that manipulation of PGRMC1 phosphorylation by mutagenesis r...
ORGANISM(S): Homo sapiens 
2019-12-01 | E-MTAB-8218 | biostudies-arrayexpress
TranscriptomicsRole of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling
In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress
GenomicsProteomic analysis of native hepatocyte nuclear factor-4{alpha} (HNF4{alpha}) isoforms, phosphorylation status, and interactive cofactors.
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18990 | biostudies-arrayexpress
ProteomicsPRM validation of phosphoproteomic and proteomic analysis of early epileptogenesis in mice at 4 and 24 h post-status epilepticus
The phosphorylation-based signalling and protein changes occurring in the early phases after a pathophysiological insult, like status epilepticus (SE), have not been detailed. In a companion project, the hippocampi of mice treated with pilocarpine and diazepam were examined by tandem mass tag (TMT11...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-22 | PXD047870 | Pride
Epileptogenesis Phospho-signalling Proteomics Epilepsy Hippocampus Synaptic weakening Signalling Phosphorylation Mouse Parallel reaction monitoring Synapse growth 
TranscriptomicsGlobal expression analysis of HNF4alpha and HNFgamma-mediated transcriptional control
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18973 | biostudies-arrayexpress
ProteomicsThe interactome of the clathrin adaptor AP2 is modulated by the phosphorylation status of its µ2 subunit.
The clathrin adaptor AP2 is phosphorylated at a single site (Thr156) of its µ2 subunit. To gain insight how phosphorylation influences the interactome of AP2, we used human RPE cells which that were treated with LP-935509, an inhibitor of the adaptor-associated kinase AAK1. Kinase inhibition and los...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013468 | Pride
Receptor Endocytosis Clathrin Aak1 Necap 
TranscriptomicsOvarian Cancer Dataset
Background. Genome-wide expression changes are associated with development of chemoresistance in patients with ovarian cancer (OVCA); the BCL2 antagonist of cell death (BAD) apoptosis pathway may play a role in clinical outcome. Methods. We analyzed specimens and/or genomic data from 1,406 patients...
ORGANISM(S): Homo sapiens 
2011-10-02 | E-GEOD-23554 | biostudies-arrayexpress
GenomicsEffect of ASCL1 phosphorylation status on chromatin binding and target regulation in neuroblastoma
Effect of ASCL1 phosphorylation status on chromatin binding and target regulation in neuroblastoma
PRJNA644293 | ENA
ProteomicsYCf1 Phosphorylation status detection using mass spect
The Purified YCF1 protein was subjected to mass-spect for phosphorylation detection.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-05-20 | PXD031330 | Pride
S. cerevisiae 
ProteomicsLISS enables immune evasion of colorectal cancers irrespective of MSI status
LISS enables immune evasion of colorectal cancers irrespective of MSI status
ORGANISM(S): Homo Sapiens 
PXD078805 |
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