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ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
UnknownDefining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Not available
S-EPMC4338609 | biostudies-literature
UnknownThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation.
Not available
S-EPMC6415872 | biostudies-literature
UnknownTGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.
Not available
S-EPMC2825893 | biostudies-literature
ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals a PP1-dependent reduction in vesicle release
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic proteins undergoing post-stimulus phospho-signalling to reveal long-lasting chang...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-24 | PXD008495 | Pride
Synaptosome Lc-ms Phosphatase Phosphorylation 
UnknownMAPPINGS, a tool for network analysis of large phospho-signalling datasets: application to host erythrocyte response to Plasmodium infection.
Not available
S-EPMC9325900 | biostudies-literature
ProteomicsCharacterization of the phospho-signalling mediated by the sodium-potassium ATPase in response to ouabain
In this project we applied a workflow for phosphoproteomics analysis to characterize the phosphorylation signalling that is triggered by the cardiotonic steroid ouabain. Ouabain is a ligand for the sodium-potassium ATPase (NKA). Low concentration of ouabain trigger oscillation of intracellular calci...
ORGANISM(S): Chlorocebus sabaeus 
2019-09-13 | PXD010006 | Pride
Phosphoproteomics Ip3r Akt Mapk Calcium-calmodulin-dependent protein kinase Nka Insp3 receptor Calcium Ouabain Na-k-atpase Sodium-potassium atpase Apoptosis Calcium oscillations Camk 
ProteomicsIdentification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer development and progression, and a role for NEK5, one of the least studied members, in breast cancer has recently been proposed. However, while NEK5 is known to regulate centrosome separation and mitotic spindle asse...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035322 | Pride
Neks  nek5  kinase  breast cancer  proteomics  bioid 
ProteomicsTemporal (phospho-)proteomic profiling of neurotrophic receptor tyrosine kinase signalling in neuroblastoma cells
Neurotrophic receptor tyrosine kinases, also known as Tropomyosin receptor kinases (TrkA, TrkB and TrkC), despite their homology, contribute to the clinical heterogeneity of childhood cancer neuroblastoma. TrkA expression is associated with low-stage disease and is often seen with spontaneous tumour...
ORGANISM(S): Homo sapiens (Human) 
2024-08-29 | PXD054441 | Pride
Neuroblastoma Trk Phosphoproteome Proteome 
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091043 | MassIVE
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