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ProteomicsOptimization of Phosphotyrosine Proteomics
We optimized a procedure of phosphotyrosine enrichment with immunoprecipitation. Then the optimized procedure was applied into a global analysis of phosphotyrosine status in culture cells treated with Erlotinib.
ORGANISM(S): Homo Sapiens (human) 
2017-09-29 | PXD005061 | JPOST Repository
TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
ProteomicsMutation-specific and common phosphotyrosine signatures of KRAS G12D and G13D alleles
KRAS is one of the most frequently mutated genes across all cancer subtypes. Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D). Although the biochemical differences between these two predomina...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD009843 | Pride
Sw48 Phosphoproteome G13d mutation G12d mutation Kras Signaling 
ProteomicsTime-resolved phosphotyrosine-proteome of Src signaling
Intracellular signaling nodes can sample multiple inputs and induce different cellular outputs. High combinatorial between their numerous potential conformational intermediaries having distinct enzymatic activities and/or repertoire of partners makes it challenging to determine their dynamic coding ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2021-02-03 | PXD008534 | Pride
Src Phosphotyrosine Signaling Nanolc-ms/ms 
ProteomicsPhosphotyrosine profiling of curcumin-induced signaling
Curcumin, derived from the rhizome of Curcuma longa is a natural anti-cancer agent and has been shown to inhibit proliferation and survival of tumor cells. Although the anti-cancer effects of curcumin are well established, detailed understanding of the signaling pathways altered by curcumin is still...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002097 | Pride
Immunoaffinity purification Curcumin Head and neck squamous cell carcinoma 
ProteomicsAutomated Enrichment of Phosphotyrosine Peptides for High-Throughput Proteomics
Phosphotyrosine (pY) enrichment is critical for expanding fundamental and clinical understanding of cellular signaling by mass spectrometry-based proteomics. However, current pY enrichment methods exhibit a high cost per sample and limited reproducibility due to expensive affinity reagents and manua...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD041271 | Pride
Hela Lc-msms Kingfisher Orbitrap eclipse Orbitrap exploris 480 Phosphotyrosine enrichment 
ProteomicspTyr-CoIP HP/AGS - Quantitative analysis of H. pylori induced phosphotyrosine signaling upon infection.
Quantitative analysis of H. pylori induced phosphotyrosine signaling upon infection.
ORGANISM(S): Homo sapiens (Human) 
2014-07-09 | PXD000722 | Pride
Human Helicobacter Ptyr 
TranscriptomicsPhosphotyrosine-mediated regulation of enterohemorhagic Escherichia coli virulence
Enteric pathogens with low infectious doses rely on the ability to orchestrate expression of virulence and metabolism-associated genes in response to environmental cues for successful infection. Accordingly, the human pathogen enterohemorrhagic Escherichia coli (EHEC) employs a complex multifaceted ...
ORGANISM(S): Escherichia coli O157:H7 str. EDL933 
2018-02-02 | GSE103764 | GEO
UnknownThe SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes.
Not available
S-EPMC4255630 | biostudies-literature
ProteomicsGlobal phosphotyrosine survey reveals activation of multiple tyrosine kinase signaling pathways in triple negative breast cancer
About 15-20% of all breast cancers are triple negative breast cancers, which are often highly aggressive. We performed global quantitative phosphotyrosine profiling of a large panel of triple negative breast cancer cell lines using high resolution Fourier transform mass spectrometry. Our study ident...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001222 | Pride
Tyrosine phosphorylation Phosphorylation Proteome Triple negative breast cancer 
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