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ProteomicsPlatelets fuel the inflammasome activation of innate immune cells
Proteomic analysis of cell-free supernatants (Secretome) from human platelets (n = 4, donors) and megakariocytes (MEG-01, n = 3 replicates).
ORGANISM(S): Homo sapiens (Human) 
2020-05-01 | PXD017976 | Pride
Innate immunity Inflammasomes Megakariocytes Platelets 
ProteomicsWater-soluble tomato extract Fruitflow alters the phosphoproteomic profile of collagen-stimulated platelets
The present study used proteomics to quantitatively analyze the effect of FF on the inhibition of collagen-stimulated platelets and validated the involvement of several signaling molecules.Fruitflow significantly inhibited human platelet aggregation and P-selectin expression that were induced by col...
ORGANISM(S): Homo Sapiens 
PXD027834 |
ProteomicsThe proteomic landscape of platelets in Glanzmann thrombasthenia
Background: Glanzmann thrombasthenia (GT) is a rare, inherited platelet function disorder caused by mutations in the integrins of the fibrinogen receptor αIIbβ3. The deficiency can be quantitative (type I/II) or qualitative (type III). This causes lack of platelet aggregation and consequently these ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PXD056734 | Pride
Glanzmann  platelets  proteomics of platelets 
ProteomicsChanges in the proteome of platelets from patients with critical progression of COVID-19
Platelets, the smallest cells in human blood known for their role in primary haemostasis, are also able to interact with pathogens and play a crucial role in the immune response. In severe coronavirus disease 2019 (COVID-19) cases, platelets become over-activated, resulting in the release of granule...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041681 | Pride
Proteomics Glucocorticoid re-ceptor Ecmo Inflammation Nfkb Acute-phase proteins Carbonic anhydrase 1 Covid-19 Platelets 
ProteomicsThrombo-Inflammation in Preeclampsia and Pregnancy Induced Hypertension: Proteomics And Metabolomics Profiling of Platelets and Plasma Mediators
Background: Platelets may be pivotal mediators of the thrombo-haemorrhagic complications of preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular dysfunction. While gestational hypertension (GH) falls within the spectrum of hypertensive complications of pregnancy and i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD031278 | Pride
Metabolomics String bg Preeclampsia Pregnancy Gestational hypertension Proteomics Pathway analysis Lrrc27/42 
ProteomicsCitrullinated proteins in platelets and platelets releasing microparticles may serve as a potential target of ACPA
To investigate the expression of peptidylarginine deiminase (PAD) enzymes and mining citrullination proteins in human platelets and platelets releasing microparticles (PRMs), and to determine whether these less-studied platelets associated citrullination proteins can be targeted by anti-citrullinate...
ORGANISM(S): Homo Sapiens 
PXD037743 |
ProteomicsAcetylated proteomic identification of stored platelets
In this project, the protein acetylation levels in human platelets and in WT and SIRT3-/- mouse platelets during storage were examined.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-09 | PXD026341 | Pride
Stored platelets  acetylation  sirt3 
ProteomicsPlasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets – secretome of platelets
Metabolomics is an emerging and powerful bioanalytical method supporting clinical investigations. Serum and plasma are commonly used without rational prioritization. Serum is collected after blood coagulation, a complex biochemical process involving active platelet metabolism. This may affect the me...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD041785 | Pride
Confounder Platelets Proteomics Metabolomics Lc-ms Plasma Serum Drug effects 
ProteomicsCyclin Y is expressed in platelets and modulates integrin outside-in signaling
Diabetes is associated with platelet hyperactivation and enhanced risk of thrombosis development. We have previously shown that calpain inhibition stabilizes the platelet proteome in diabetic patients. However, a global proteome analysis comparing platelets from healthy donors and from diabetic pati...
ORGANISM(S): Homo sapiens (Human) 
2021-05-31 | PXD021271 | Pride
Proteomics Platelets Diabetes 
ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
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