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TranscriptomicsTranscription profiling of human osteosarcoma Sa OS cells vs reference RNA of human osteosarcoma U-2 OS cells
Osteosarcoma (OS) is a common primary bone malignancy that is characterized by high degree of aneuploidy, gene amplification, and multiple unbalanced chromosomal rearrangements. The human osteosarcoma U-2 OS and Sa OS cells lines have been generated more than three decades ago and are used in a wide...
ORGANISM(S): Homo sapiens 
2009-09-21 | E-MEXP-1897 | biostudies-arrayexpress
GenomicsHomo sapiens strain:U-2 OS
Homo sapiens strain:U-2 OS Targeted Locus (Loci)
PRJNA298919 | ENA
ProteomicsProximity proteomics of phagophore-associated proteins using APEX2-LC3B in VPS37A KO U-2 OS cells
We utilized an APEX2-mediated proximity biotinylation approach to label proteins on LC3-positive membranes that accumulate in VPS37A-knockout (KO) U-2 OS cells. AP, APEX2 control; WT, APEX2-LC3B.
ORGANISM(S): Homo sapiens (Human) 
2024-12-03 | PXD057301 | Pride
Human Vps37a ko u-2 os cells Autophagosomal membrane Phagophore Apex2-lc3b 
TranscriptomicsRNAi profiling by array of human U-2-OS osteosarcoma cells with knockdown of Asf1a and Asf1b
We used RNAi to knock-down the two isoforms of Asf1, Asf1a and Asf1b, in human U-2-OS osteosarcoma cells. We obtained two replicates each with siRNAs against Asf1a, Asf1b, combined siRNAs against both isoforms, and two control samples. For these samples, we measured genome-wide transcription levels ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-MEXP-2671 | biostudies-arrayexpress
GenomicsRNA-seq profiling of U-2 OS osteosarcoma cells expressing scrambled control or Timeless shRNA
RNA-seq profiling of U-2 OS osteosarcoma cells expressing scrambled control or Timeless shRNA
PRJNA1498013 | ENA
ProteomicsSILAC phosphoproteome analysis upon transient Abl1/2 or DDR1 knockdown in human U-2 OS cells
Analysis of changes in the phosphoproteome upon transient siRNA-mediated knockdown of ABL1/ABL2 or DDR1 for 48 hours. CILAC phosphoproteome analysis was conducted after 48hrs using human U-2 OS cells.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD023146 | Pride
Abl2 Silac Abl1 Ddr1 
TranscriptomicsGene Regulation by the Human Glucocorticoid Receptor Dimerization Domain Mutant dim4
A mutation in the dimerization domain of the mouse glucocorticoid receptor (GR), dim1, has recently been shown to bind DNA and regulate gene expression. To expand these studies we created a stable osteosarcoma (U-2 OS) cell line expressing four mutations in the dimerization domain of the human GR, ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26857 | biostudies-arrayexpress
ProteomicsLOPIT-DC subcellular map of U-2 OS cells
Generation of a high-resolution subcellular localisation map for the proteome of the human cancer cell line U-2 OS, using the newly developed LOPIT-DC method. Comparison of the results generated using LOPIT-DC with data generated using the well-established hyperLOPIT method and data mining regarding...
ORGANISM(S): Homo sapiens (Human) 
2019-01-23 | PXD011254 | Pride
Lopit-dc Hyperlopit Cancer subcellular map Spatial proteomics 
GenomicsHomo sapiens
RNA sequencing of U-2 OS and U-2 OS hTERT GFP
PRJNA1153800 | ENA
TranscriptomicsExpression data from U-2 OS osteosarcoma cell lines stably expressing an S22A-progerin mutant compared with U-2 OS expressing wt-progerin
Disassembly of the nuclear envelope is an essential feature of mammalian cell division controlled by the phosphoryaltion of lamins via cyclin dependent kinases. This process is affected in cells expressing progerin, a lamin A allele found in patients with Hutchinson-Gilford Progeria syndrome. Proger...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-51349 | biostudies-arrayexpress
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