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ProteomicsFunctional characterization of the p97/valosin-containing protein (VCP) interacting network in Leishmania Functional characterization of the p97/valosin-containing protein (VCP) interacting network in Leishmania
Valosin‐containing protein (VCP)/p97/Cdc48 is an essential AAA+ ATPase associated with many ubiquitin-dependent cellular pathways that plays a central role in protein quality control in all eukaryotes. Its functional diversity relies on its ability to cooperate with a large number of protein cofacto...
ORGANISM(S): Leishmania infantum JPCM5 
2020-08-06 | PXD013731 | Pride
Leishmania  vcp/p97  vcp cofactors  co-immunoprecipitation  lc-ms/ms  network proteomics 
UnknownThe general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.
Not available
S-EPMC3207395 | biostudies-literature
Proteomicsp97/VCP is required for piecemeal autophagy of aggresomes
Metazoan cells adapt to the exhaustion of protein quality control (PQC) systems by sequestering aggregation-prone proteins in large, pericentriolar structures termed aggresomes. Defects in both, aggresome formation and clearance affect proteostasis and have been linked to neurodegenerative diseases,...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD053581 | Pride
Aggrephagy Proximity proteomics Turboid Protein quality control Tax1bp1 P97/vcp Piecemeal autophagy 
ProteomicsVCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD043563 | Pride
Fam104a Vcf Vcp Ubiquitin P97 
UnknownThe structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97.
Not available
S-EPMC3207442 | biostudies-literature
UnknownEndolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.
Not available
S-EPMC3246400 | biostudies-literature
ProteomicsInduced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex
The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the various p97 cofactors involved. Here, we combined ubiquitin profiling with acutely induced degradation...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD082712 | Pride
Dna damage Replication Ubiquitin Vcp Cohesin 
ProteomicsAP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation
The ubiquitin-directed AAA-ATPase VCP/p97 facilitates degradation of misfolded proteins in diverse cellular stress response pathways. Resolving the complexity of dynamic interactions with hosts of accessory proteins and substrates has therefore been a major challenge. Here, we used affinity-purifica...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD007876 | Pride
Integrated stress response Ap-swath P97 
UnknownThe AAA + ATPase valosin-containing protein (VCP)/p97/Cdc48 interaction network in Leishmania.
Not available
S-EPMC7403338 | biostudies-literature
GenomicsInduced ubiquitination drives ER protein degradation through a VCP-dependent pathway
Induced ubiquitination drives ER protein degradation through a VCP-dependent pathway
PRJNA1530958 | ENA
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