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ProteomicsYTHDF2 regulates self non-coding RNA metabolism to control TLR3 activation in Inflammation
To elucidate the roles of YTHDF2 in the UV response in Human Keratinocyte (HaCaT) cells, the YTHDF2 interactome was analyzed through immunoprecipitation using a YTHDF2-specific antibody. Control IgG served as a negative control in this study. The cells were treated with UVB at 20 mJ/cm², and one hou...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD059422 | Pride
U6 Cancer Ythdf2 Tlr3 Inflammation M6a Snrna Rna methylation Uvb 
ProteomicsP0 B6 mouse forebrain Ythdf2 LC-MS/MS
For P0 B6 mouse forebrain, to investigate the interacting protein partners with Ythdf2 with m6A, we compared the Mettl14 Nestin-Cre condition knockout mouse with WT mouse and changed the condition for IgG pulldown and Ythdf2 antibody pulldown.
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD080605 | Pride
Mouse Forebrain Ythdf2 Lc-ms/ms 
GenomicsYTHDF2 irCLIP-seq
YTHDF2 irCLIP-seq
PRJNA422164 | ENA
ProteomicsO-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to be O-GlcNAcylated on Ser-263 during Hepatitis ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD045137 | Pride
O-glcnac  m6a  c-myc  erk  lung carcinoma 
GenomicsAnti-YTHDF2 RIP-Seq to identify YTHDF2 target mRNAs in hippocampus
Anti-YTHDF2 RIP-Seq to identify YTHDF2 target mRNAs in hippocampus
PRJNA720917 | ENA
TranscriptomicsMicroarray data from YTHDF2-deficient pre-leukemic cells and control pre-leukemic cells
YTHDF2 is overexpressed in a broad spectrum of human acute myeloid leukemias (AML). To study the role of YTHDF2 in leukemia, c-Kit+ cells from foetal livers of Ythdf2fl/fl;Vav-iCre (Ythdf2CKO) and Ythdf2fl/fl (Ythdf2CTL) 14.5 dpc embryos were transduced with Meis1 and Hoxa9 oncogenes and serially re...
ORGANISM(S): Mus musculus 
2019-04-05 | E-MTAB-6783 | biostudies-arrayexpress
ProteomicsNANOS3-YTHDF2 mediated P-Body assembly disturbs folliculogenesis in offspring with maternal exposure to AAI
Post-transcriptional RNA regulation is critical for the formation of primordial follicles, which determine female reproductive potential. Stress-induced disruptions in RNA metabolism are increasingly recognized as key factors impairing oogenesis, but the underlying mechanisms remain poorly understoo...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD058281 | Pride
Aristolochic acid ⅰ  nanos3  ythdf2  p-body  folliculogenesis 
GenomicsAnti YTHDF2 RIP-seq to identify YTHDF2 target mRNAs in P0 mouse retinas
Anti YTHDF2 RIP-seq to identify YTHDF2 target mRNAs in P0 mouse retinas
PRJNA607064 | ENA
GenomicsYTHDF2 iCLIP in glioblastoma stem cells
YTHDF2 iCLIP in glioblastoma stem cells
PRJNA663772 | ENA
GenomicsZNF121 recruits YTHDF2 to modulate mRNA stability
ZNF121 recruits YTHDF2 to modulate mRNA stability
PRJEB101442 | ENA
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