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ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
ProteomicsRatio accuracy evaluation and correction using tandem mass tags
The multiplexing capabilities of isobaric mass tag based protein quantification, such as Tandem Mass Tags (TMT) or Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) have dramatically increased the scope of Mass Spectrometry (MS) based proteomics studies. Not only does the technology allow ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-27 | MSV000082855 | MassIVE
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-24 | PXD011691 | Pride
Tmt Orbitrap fusion lumos Dia 
ProteomicsPeli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis
The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis since the knock-out induced less activated microglia and less inflammation in the CNS of experimental autoimmune encephalomyelitis in mice. In the present study the brain proteomes of Peli1...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003710 | Pride
Tmt Label-free Eae Cns Peli1 Multiple sclerosis Quantitative proteomics 
ProteomicsQuantitative Proteomic Profiles of Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is a common, adult B-cell leukaemia that has challenges in prognosis and treatment. It is characterised by a heterogeneous clinical course with multiple distinct phenotypes currently defined genetically or with target-specific monoclonal antibodies...
ORGANISM(S): Homo sapiens (Human) 
2018-01-26 | PXD002004 | Pride
Bridging controls Cancer Cll Tmt Leukaemia Whole cell 
ProteomicsTMT-based Quantitative Proteomics of Developing Sea Buckthorn (Hippophae rhamnoides) Berries Reveals Candidate Proteins Related to Lipid Metabolism
Sea buckthorn (Hippophae rhamnoides L.) is an economically important shrub or small tree indigenous to Asia and Europe. The most well-recognized medicinal and nutraceutical products derive from the berry oil, which is rich in essential fatty acids, monounsaturated palmitoleic acid (16:1 ω-7), linole...
ORGANISM(S): Hippophae rhamnoides subsp. mongolica 
2019-04-18 | PXD009365 | Pride
Proteomics Hippophae rhamnoides Lipid metabolism Tmt-based quantitative 
ProteomicsPandanus amaryllifolius drought stress and recovery LC-MSMS TMT-Labelled
The aim of this project is to determine the protein changes of P. amaryllifolius in response to drought stress and during recovery. The protein changes between drought-stressed, well-watered, and recovered plants were evaluated using tandem mass tags (TMT)-based quantitative proteomics. The proteins...
ORGANISM(S): Pandanus amaryllifolius 
2022-02-16 | PXD028784 | Pride
Lc-msms Drought stress Abiotic stress Pandanus amaryllifolius Tmt-labelled Recovery 
ProteomicsTesting TMT-SPS-MS3 and label free approach in recalcitrant Mago (Mangifera indica L.) peel tissues
Significant progress has been observed in recent years in proteomics tools. However, minimal application of the newest proteomic tools has been massively applied in plant recalcitrant tissues in non-model fruits. This constant occurrence constrains the progress in understanding essential molecular p...
ORGANISM(S): Mangifera indica (Mango) 
2024-01-29 | PXD040720 | Pride
Protein extraction Proteomics Postharvest shelf life Mango peel 
ProteomicsLabel-based proteomic comparison of four Persimon cultivars from south Italy
Differentiation of Persimmon ecotypes by label-based proteomics analysis. The aim of the study is to identify quantitative differences in proteomic profile occurring in the fruits harvested at commercial ripening. The proteomic data obtained by TMT-based analysis will be related to agronomic data, c...
ORGANISM(S): Diospyros kaki 
2023-03-11 | PXD037485 | Pride
Persimon Cultivar comparison Tmt Qexactive 
ProteomicsGlobal quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
Patients with Alzheimer’s disease (AD) and Parkinson disease (PD) often have overlap in brain neuropathology and clinical presentation suggesting that these two diseases share common underlying mechanisms. Currently, the molecular events linking AD and PD are incompletely understood. Utilizing 10-p...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD007160 | Pride
Brain Tmt Human Sps Parkinson's Alzheimer's Lc-ms/ms 
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