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UnknownThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
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S-EPMC7873184 | biostudies-literature
ProteomicsThe methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3- methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-11-23 | PXD022067 | Pride
Metylation histidine mettl9 
UnknownMETTL9 sustains vertebrate neural development primarily via non-catalytic functions.
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S-EPMC12313917 | biostudies-literature
UnknownThe Hydrogen Bonded Structures of Two 5-Bromobarbituric Acids and Analysis of Unequal C5-X and C5-X' Bond Lengths (X = X' = F, Cl, Br or Me) in 5,5-Disubstituted Barbituric Acids.
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S-EPMC5493196 | biostudies-literature
ProteomicsProSeAM SILAC MS screening for METTL9 substrates
Click chemistry based substrates screening for METTL9 in Mettl9 KO MEF cells.
ORGANISM(S): Mus Musculus (mouse) 
2020-11-19 | PXD016823 | JPOST Repository
ProteomicsHistidine methylation of MYLK2 and C3H zinc fingers by CARNMT1
We here describe our independent uncovering of CARNMT1 as a protein histidine methyltransferase (HMT), and our extensive efforts on defining its substrate specificity and methylation targets. We found that recombinant CARNMT1 methylated MYLK2-derived peptide containing His-148 in vitro. The recombin...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2025-07-28 | PXD060821 | Pride
C3h zinc finger 1mh 1-methylhistidine Mylk2 Spliceosome Histidine methyltransferase Rnf113a Protein methylation Carnmt1 U2af1 
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