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GenomicsThe X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
PRJNA549715 | ENA
TranscriptomicsThe X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
We report a global impact of the depletion of RNF113A on splicing, especially in cells treated with cisplatin.
ORGANISM(S): Homo sapiens 
2020-03-11 | GSE133029 | GEO
UnknownKDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damage.
Not available
S-EPMC12776375 | biostudies-literature
GenomicsHomo sapiens
HeLa cells (Control and RNF113A KO)
PRJNA1096255 | ENA
UnknownThe X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage.
Not available
S-EPMC7062854 | biostudies-literature
UnknownSMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
Not available
S-EPMC9437563 | biostudies-literature
GenomicsHomo sapiens
BEAS-2B WT and RNF113A deltaC raw RNA sequencing reads
PRJNA1456528 | ENA
UnknownEIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.
Not available
S-EPMC10243067 | biostudies-literature
ProteomicsHistidine methylation of MYLK2 and C3H zinc fingers by CARNMT1
We here describe our independent uncovering of CARNMT1 as a protein histidine methyltransferase (HMT), and our extensive efforts on defining its substrate specificity and methylation targets. We found that recombinant CARNMT1 methylated MYLK2-derived peptide containing His-148 in vitro. The recombin...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2025-07-28 | PXD060821 | Pride
C3h zinc finger 1mh 1-methylhistidine Mylk2 Spliceosome Histidine methyltransferase Rnf113a Protein methylation Carnmt1 U2af1 
TranscriptomicsAberrant RNA methylation triggers recruitment of an alkylation repair complex
Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the activation of the ASCC-ALKBH3 repair pathway is exquisitely specific to alkylation damage in human cells. Yet the mechanistic basis for the se...
ORGANISM(S): Homo sapiens 
2021-02-01 | GSE158090 | GEO
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