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GenomicsChromatin 3D interactions mediate genetic effects on gene expression
Studying the genetic basis of gene expression and chromatin organization is key to characterize the effect of genetic variability on the function and structure of the human genome. Here, we unravel how genetic variation perturbs gene regulation using a dataset combining activity of regulatory elemen...
EGAS00001003485 | EGA
GenomicsOncogene-Mediated Alterations in Chromatin Conformation
Emerging evidence suggests that chromatin adopts a non-random three-dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how on...
ORGANISM(S): Homo sapiens 
2012-05-23 | E-GEOD-37752 | biostudies-arrayexpress
GenomicsNuclear exosome targeting complexes modulate 3D chromatin interactions genome-wide
Nuclear exosome targeting complexes modulate 3D chromatin interactions genome-wide
PRJNA1191522 | ENA
ProteomicsMultiomic analysis of Cohesin reveals that ZBTB transcription factors contribute to chromatin interactions
One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we performed proteomic profiling of the Cohesin in chromatin and id...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-05 | PXD028860 | Pride
Human Label-free Mouse Hek293ts Chip-ms Mescs 
ProteomicsMultiomic analysis of Cohesin reveals that ZBTB transcription factors contribute to chromatin interactions
One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we performed proteomic profiling of the Cohesin in chromatin and id...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-05 | PXD036004 | Pride
Human Ch12f3 Label-free Mouse Hek293ts Chip-ms B16 Mescs 
ProteomicsMultiomic analysis of Cohesin reveals that ZBTB transcription factors contribute to chromatin interactions
One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we performed proteomic profiling of the Cohesin in chromatin and id...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-05 | PXD035893 | Pride
Human Ch12f3 Label-free Mouse Hek293ts Chip-ms B16 Mescs 
TranscriptomicsVariation and genetic control of chromatin architecture in humans (RNAseq)
This data set comprises population (46 samples) measurements of RNA expression levels for a subset of the 1000 Genomes Project CEPH samples. This data was generated as part of the following study: - Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Cell. 2015 Aug ...
ORGANISM(S): Homo sapiens 
2016-05-27 | E-MTAB-3656 | biostudies-arrayexpress
GenomicsArchitectural protein subclasses shape 3-D organization of genomes during lineage commitment
Understanding the topological configurations of chromatin can reveal valuable insights into how the genome and epigenome act in concert to control cell fate during development. Here we generate high-resolution architecture maps across seven genomic loci in embryonic stem cells and neural progenitor...
ORGANISM(S): Mus musculus 
2013-05-24 | E-GEOD-36203 | biostudies-arrayexpress
GenomicsVariation and genetic control of chromatin architecture in humans (ChIPseq)
This data set comprises population (47 samples) measurements of transcription factor DNA binding (PU.1 and RPB2) and histone modification (H3K27ac, H3K4me1 and H3k4me3) levels for a subset of the 1000 Genomes Project CEPH samples. This data was generated as part of the following study: - Population ...
ORGANISM(S): Homo sapiens 
2019-03-14 | E-MTAB-3657 | biostudies-arrayexpress
GenomicsGlobal Reorganization of Chromatin Architecture during Embronic Stem Cell Differentiation
The 3D organization of the genome is important for regulation of diverse nuclear processes ranging from transcription to DNA replication. Knowledge of the higher order chromatin structure is critical for understanding mechanisms of gene regulation by long-range control elements such as enhancers and...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-52457 | biostudies-arrayexpress
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