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ProteomicsProtein profiling of 6-OHDA induced PD Model treated by TBN
Parkinson's disease (PD) listed as the second most common neurodegenerative disease. 2-[[(1,1-Dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has shown benefits for the treatment both in vitro and in vivo, TBN protects and rescues d...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-03-02 | PXD004812 | Pride
Tbn Rat model 6-ohda Parkinson's disease 
ProteomicsChemoproteomic Profiling of Reactive Cysteines in Response to Oxidative Stress Induced by 6-Hydroxydopamine
Oxidative stress is a well-known driver of neurodegeneration, yet it remains poorly understood how the global cysteine (Cys) proteome is remodeled in such conditions. Proteins with aberrantly modified Cys in response to oxidative stress can induce and exacerbate neurodegeneration. In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD060980 | Pride
Quantitative proteomics Cell stress response Sh-sy5y Oxidative stress Neurodegeneration Neurodegenerative signaling 6-hydroxydopamine Cysteine proteomics 
GenomicsTranscriptomic study identifies quercetin and rutin as repurposed drugs for Parkinson’s Disease in in vitro 6-OHDA model
Transcriptomic study identifies quercetin and rutin as repurposed drugs for Parkinson’s Disease in in vitro 6-OHDA model
PRJNA813345 | ENA
TranscriptomicsTranscription profiling by array of newt midbrain ependymoglia cells after 6-OHDA mediated ablation of midbrain dopamingeric neurons
Effect of 6-OHDA mediated ablation of midbrain dopamingeric neurons on the transcriptional profile of midbrain ependymoglia cells (neuronal stem cells) in newts.
ORGANISM(S): Notophthalmus viridescens 
2011-05-31 | E-MEXP-2752 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat brain response to 6-OHDA-treatment
influence of 6-OHDA-treatment on Rat-brain gene expression
ORGANISM(S): Rattus norvegicus 
2013-01-30 | E-RZPD-3 | biostudies-arrayexpress
TranscriptomicsTranscriptomic study identifies quercetin and rutin as repurposed drugs for Parkinson’s Disease in in vitro 6-OHDA model
SH-SY5Y cells were treated with 6-hydroxydopamine (6-OHDA) to obtain an in vitro PD model. Transcriptome data were collected from both treated and untreated cells.We mapped significantly upregulated genes on a protein-protein interaction network to identify potential drug targets. Drugs targeting th...
ORGANISM(S): Homo sapiens 
2023-01-01 | GSE198009 | GEO
Genomics
BV2 microglial cell + 6-OHDA + CDNF
PRJNA821327 | ENA
TranscriptomicsProtection of SH-SY5Y cells against 6-OHDA by 3,4-dihydroxybenzalacetone (DBL) and caffeic acid phenethyl ester (CAPE)
3,4-dihydroxybenzalacetone (DBL) and Caffeic acid phenethyl ester (CAPE) are both catechol-containing phenylpropanoid derivatives. In the present study, we compared the neuroprotective characteristics of these compounds and other phenylpropanoid derivatives against Parkinson’s disease-related neurot...
ORGANISM(S): Homo sapiens 
2020-01-31 | GSE93639 | GEO
TranscriptomicsBulk RNA-seq of striatum of 6-OHDA lesioned rats exposed to levodopa/benserazide and trapidil
Gene expression changes in striatum of 6-OHDA lesioned female Sprague Dawley rats due to 14 days of daily dosing of levodopa/benserazide with or without trapidil.
ORGANISM(S): Rattus norvegicus 
2026-07-15 | GSE278287 | GEO
UnknownQuercetin alleviates 6-OHDA-caused apoptosis in SH-SY5Y cells.
Not available
S-EPMC11295208 | biostudies-literature
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