Sort   by:  
 Page size 
MetabolomicsDivergent relationships between faecal microbiota and metabolome following distinct antibiotic-induced disruptions
The intestinal microbiome plays an essential role in regulating many aspects of host physiology, and its disruption through antibiotic exposure has been implicated in the development of a range of serious pathologies. The complex metabolic relationships that exist between members of the intestinal m...
2017-03-03 | MTBLS422 | MetaboLights
ProteomicsDevelopment and characterization of selective FAK inhibitors and PROTACs with in vivo activity
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors and cellular processes. While drug discovery efforts have largely focused on targ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039828 | Pride
Fak Inhibitor Protac Degrader 
ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
ProteomicsSpinal cord phosphoproteome of SCA2/ALS13 mouse model
Toxic polyglutamine (polyQ) expansions in ATXN2 trigger neurodegenerative processes, causing Spinocerebellar Ataxia type 2 (SCA2), and enhancing TDP 43-dependent pathology in Amyotrophic Lateral Sclerosis (ALS) / Fronto-Temporal Dementia (FTD). Primary disease events can be compensated transiently, ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD062823 | Pride
Fe-nta binding  imac  cortico-spinal motoneurons  cerebellar purkinje neurons  tyrosine receptor endocytosis  intrinsically disordered domains  liquid-liquid phase separation  proteasome  aggrephagy  microtubule-organizing center. 
UnknownA Rationally Designed Reversible 'Turn-Off' Sensor for Glutathione.
Not available
S-EPMC5618042 | biostudies-literature
UnknownMulti-dimensional-double-spiral (MDDS) inertial microfluidic platform for sperm isolation directly from the raw semen sample.
Not available
S-EPMC8913683 | biostudies-literature
ProteomicsANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
Phase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. Recent work has raised the intriguing prospect that phase transitions in proteins and lipids can be co-regulated. Here we investigate this possibility in the rib...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD060971 | Pride
Lc-msms Rnp granules Anxa11 
UnknownChlorpromazine for schizophrenia: a Cochrane systematic review of 50 years of randomised controlled trials.
Not available
S-EPMC1274318 | biostudies-literature
UnknownBiotin Protein Ligase Is a Target for New Antibacterials.
Not available
S-EPMC5039522 | biostudies-literature
UnknownUnraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.
Not available
S-EPMC4156867 | biostudies-literature
Sort   by:  
 Page size