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ProteomicsOn-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
Here we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of MALDI N-glycan MSI and spatially-resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuA...
ORGANISM(S): Canis lupus 
2023-03-11 | PXD025826 | Pride
Glioblastoma Spatially-resolved Glycoproteomics Haptoglobin Sialic-acid Maldi-msi Hypersialylation Glycan-imaging 
UnknownStratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles.
Not available
S-EPMC12679798 | biostudies-literature
ProteomicsQuick steps to get glioma extracellular vesicles surface membrane proteins mapping based on tryspin/Lysin C digestion followed by Amicon and shot gun proteomic: identification of ghost protein
Extracellular vesicles (EVs) are known to mediate intercellular communication and regulate a diverse range of crucial biological processes. Novel therapeutic strategies have emerged based on these EVs as biological nanoparticles. EVs is as a generic term for all secreted vesicles released including ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-12 | PXD016944 | Pride
Glioma Vesicle Ghost-protein Lc-msms 
ProteomicsOn-tissue spatially-resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape
Here we present an approach to identify N-linked glycoproteins and deduce their spatial localization using a combination of MALDI N-glycan MSI and spatially-resolved glycoproteomics. We subjected glioma biopsies to on-tissue PNGaseF digestion and MALDI-MSI and found that the glycan HexNAc4-Hex5-NeuA...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-05-04 | PXD025537 | Pride
Glioblastoma Spatially resolved glycoproteomics Glycoproteomics Glycan imaging Haptoglobin Sialic acid Spatially resolved glycoproteomicsglycan imaging Maldi-msi Hypersialylation 
UnknownOn-tissue spatially resolved glycoproteomics guided by N-glycan imaging reveal global dysregulation of canine glioma glycoproteomic landscape.
Not available
S-EPMC8617081 | biostudies-literature
ProteomicsSentinel Lymph Node and Endometrial Cancer Grade in depth Proteomic Analyses : A Novel Approach for Molecular Diagnosis
Endometrial cancer is the most common gynecological cancer worldwide. In women from developed countries, endometrial cancer is usually detected after the age of 60 years. Nearly 90% of the diagnosed cases are sporadic, while 10% are attributed to genetic factors. Thus, it is necessary to develop a d...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020410 | Pride
Ghost proteome Endometrial cancer Proteomic Diagnosis Sentinel lymph nodes Protein mutations Small prot 
ProteomicsOptimizing Small and Large Brain-Derived Extracellular Vesicle Purification Reveals Critical Pathways in Alzheimer's Disease Patients
At this day, Alzheimer’s disease is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propagation hypothesis implicating a transfer of pathological tau seeds from cell-to-cell...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD055734 | Pride
Clu Collagenase brain dissociation Fermt2 Extracellular vesicles Gwas Proteomic profiling Alzheimer's disease 
ProteomicsHistone proteomic associated with epigenetic studies revealed a Ghost proteome in PC1/3 KD macrophages involved in anti - tumoral resistance under IL - 10 stimulation
In our previous work, our investigation on macrophages has allowed us to show that the inhibition of the enzyme proprotein convertase (PC1/3) controls the activation of macrophages. We demonstrated that PC1/3 knockdown (KD) in macrophages would exhibit an increased secretion of pro-inflammatory and ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-02-12 | PXD020610 | Pride
Macrophage Lc-msms Altprots Histone Epigenetic 
ProteomicsCORRELATION OF CANINE BONE MARROW DERIVED MESENCHYMAL STEM CELLS GENOMICS WITH SECRETOME PROTEOMIC COMPOSITION
The adult stem cells have become prominent candidates for the treatment of various diseases in veterinary practice. Therefore, the main goal of our study was to provide a complex study of canine bone marrow derived mesenchymal stem cells (BMMSCs) and conditioned media, isolated from healthy adult do...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2019-07-15 | PXD013058 | Pride
Lc-msms Stem-cell Proteomic Secretome Canine 
ProteomicsAssessing the effect of number of single hit vs. 3 repetitive hits in a mouse of closed head injury (rCHI) at 3 and 7 days post injury (DPI) in the cortex and hippocampus tissue
Mouse model of closed head injury (rCHI) was assessed for the effect of single hit vs. repetitive hits (3 hits) on the behavioral, biochemical and neuroproteomics changes at the acute (3 days) and sub chronic (7 days) time points in the cortex and hippocampus brain regions. This study will assess th...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD011418 | Pride
Mouse Hippocampus Cortex Neuroproteomics Closed head injury 
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