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ProteomicsAcid bone lysates: what we eliminate by preparing demineralized bone matrix
Demineralized bone matrix is a widely used allograft where not only the inorganic mineral but also embedded growth factors are removed by hydrochloric acid. The cellular response to the growth factors released during the preparation of demineralized bone matrix, however, has not been studied. Here w...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2018-11-04 | PXD010145 | Pride
Growth factors Bone matrix Acid bone lysates 
UnknownBone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts.
Not available
S-EPMC10671348 | biostudies-literature
ProteomicsDistinct Extracellular Matrix Protein Signatures of Cortical and Cancellous Bone Allografts Following Processing for Clinical Use
Demineralized bone matrices (DBMs) are widely used in bone replacement therapy. Bone tissue of either cancellous or cortical origin is decellularized, demineralized, and sterilized during processing, while retaining portions of native organic extracellular matrix (ECM) proteins that regulate cell-ma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD075611 | Pride
ProteomicsSynergistic potential of sulfated hyaluronic acid and dexamethasone
Both sulfated hyaluronic acid and dexamethasone are candidates for the functionalization of bone grafts as they were shown to enhance the differentiation of osteoblasts from bone marrow stromal cells in vitro and in vivo. However, the underlying mechanisms are not fully understood. Furthermore, stud...
ORGANISM(S): Homo sapiens (Human) 
2019-03-15 | PXD009434 | Pride
Human Hbmsc Lc-msms Sulfated hyluronic acid Osteoblasts Dexamethasone 
TranscriptomicsTranslating transcriptome of cancer cells in situ in mesenchymal-rich tumor microenvironment
A mesenchymal rich stroma such as cancer-associated fibroblasts (CAFs) in breast tumors favors the selection of cancer clones with enhanced bone metastatic ability. To determine the cancer cell transcriptomic response to the mesenchymal stroma, we supplemented experimental mammary tumours with or wi...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43306 | biostudies-arrayexpress
ProteomicsProteomic anlaysis of bone marrow from Dmp1Cre.Socs3f/f.Csf3r-/- mice
To identify the mechanisms regulating osteoblasts and osteoclasts in Dmp1Cre.Socs3f/f.Csf3r-/- mice, we performed a proteomic analysis of their bone marrow compared to littermate Dmp1Cre.Socs3f/f controls.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-02 | PXD057179 | Pride
G-csf receptor Stat3 Bone marrow 
ProteomicsSecretome analysis of human bone marrow derived mesenchymal stromal cells
As an essential cellular component of the bone marrow (BM) microenvironment mesenchymal stromal cells (MSC) play a pivotal role for the physiological regulation of hematopoiesis, in particular through the secretion of cytokines and chemokines. Mass spectrometry (MS) facilitates the identification an...
ORGANISM(S): Homo sapiens (Human) 
2019-02-12 | PXD011643 | Pride
Bone marrow Mesenchymal stromal cells Hematopoiesis Secretome 
GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
ProteomicsProteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056221 | Pride
Dcaf8  bone marrow  aging 
ProteomicsUbiquitin proteomic analysis of bone marrow cells from wild-type and Dcaf8 knockout mice
To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted ubiquitin proteomic analysis on bone marrow cells from wild-type an...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-04 | PXD056263 | Pride
Dcaf8  bone marrow  aging 
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