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GenomicsTranscriptome analysis of ACKR3+ and ACKR3- Marginal Zone B cells (MZBs) in mice
Transcriptome analysis of ACKR3+ and ACKR3- Marginal Zone B cells (MZBs) in mice
PRJNA523538 | ENA
ProteomicsStimulation of the atypical chemokine receptor 3 inhibits connexin 43 gap junctional intercellular communication
The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in various tumors promotes cell proliferation and invasiveness. The intracellular cellular pathways transducing ACKR3-dependent effects remain poorly char...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD016978 | Pride
Chemiokines Cx43 Ackr3 Hek293t 
ProteomicsACKR3 conformational changes upon nanobody binding
Here we used Hydrogen/Deuterium exchange mass spectrometry (HDX-MS) to examine the binding mode and mechanism of action of various nanobodies on ACKR3.
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD051149 | Pride
Hdx-ms Nb Gpcr 
GenomicsACKR3 promotes CXCL12/CXCR4-mediated migration of lymphoma cells
ACKR3 promotes CXCL12/CXCR4-mediated migration of lymphoma cells
PRJNA715443 | ENA
TranscriptomicsTranscriptome analysis of ACKR3+ and ACKR3- Marginal Zone B cells (MZBs) in mice
The marginal zone (MZ) of the spleen contains a specialized set of innate-like B cells that are in direct contact with the blood. Here we show that expression of the atypical chemokine receptor 3 (ACKR3) defines two phenotypically, transcriptionally and functionally distinct, equal-sized populations...
ORGANISM(S): Mus musculus 
2020-06-19 | GSE126860 | GEO
ProteomicsACKR3 Degradation by the Novel Scutellarein Derivative TBS6b Potently Suppresses Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) remains a formidable challenge in oncology due to its aggressive nature and limited treatment options. Scutellarein, derived from the traditional Chinese herb Scutellaria baicalensis, has shown potential against HCC, albeit with limited efficacy. To enhance its therape...
ORGANISM(S): Homo sapiens (Human) 
2024-08-16 | PXD053819 | Pride
Ackr3 Hcc Hcclm3 Tbs6b Lc-ms/ms 
TranscriptomicsACKR3 promotes CXCL12/CXCR4-mediated migration of lymphoma cells
Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphoma cell migration towards CXCL12. Here, we propose ...
ORGANISM(S): Homo sapiens 
2022-10-13 | GSE169144 | GEO
UnknownAdipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue.
Not available
S-EPMC8067615 | biostudies-literature
GenomicsRNA seq of ACKR3 loss in LUSC murine cell lines derings from genetically engineereed mouse models
RNA seq of ACKR3 loss in LUSC murine cell lines derings from genetically engineereed mouse models
PRJNA1304592 | ENA
UnknownACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Not available
S-EPMC8983782 | biostudies-literature
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