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ProteomicsComputational Prediction, Validation and Repurposing of Existing Drug as Inhibitor of Vascular Calcification
This study aimed to identify small molecules that inhibit vascular calcification with computational approach. To examine the mechanism of calcification inhibition, proteomics analysis was performed using aorta tissue samples to clarify therapeutic target.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD029963 | Pride
Vascular calcification Proteomics Mice Wnt signaling Drug discovery Drug repurposing 
ProteomicstMS2/PRM on fibrotic valve tissue
tMS2 scan on ENO2, TUJ1 and GFAP from a donor valve
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025872 | Pride
Aortic valve Human 
ProteomicsHuman iPSCs differentiated into SMCs
Human iPSCs were differentiated towards an induced-SMC (iSMC) phenotype in a 10-day protocol. Proteomics was performed throughout the entire differentiation time course to provide a robust, well-defined starting and ending cell population. Proteomics data verified iPSC differentiation to iSMCs. Prot...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032353 | Pride
Calcification Smooth muscle cell Lumos 
ProteomicsMitochondrial extracellular vesicles promote aortic valve calcification via carnitine O-octanoyltransferase
Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular morbidity and mortality with no effective medical therapy. We previously identified carnitine O-octanoyltransferase (CROT) as a mediator of mitochondrial dysfunction and vascular calcification. However, its role in CAVD remain...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-05-13 | PXD072508 | Pride
Mitochondrial extracellular vesicles Aortic valve calcification Mitochondria Valvular interstitial cells Lc-ms/ms 
ProteomicsCarnitine O-octanoyltransferase is a novel inducer of vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction
Objective – Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no FDA-approved anti-calcific therapies. We hypothesized and validated that an unbiased screening approach would identify novel mediators of human vascular calcification. Ap...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD022575 | Pride
Human primary smooth muscle cells Crot Cardiovascular calcification 
ProteomicsSexual Dimorphism of Plasma Proteomes in Human Calcific Aortic Valve Stenosis
Females are underrepresented in studies of calcific aortic valve stenosis (CAVS), leading to delay in timely intervention and increased mortality. Histopathology demonstrates female CAVS presents with decreased valvular calcification but increased fibrosis and severity of symptoms. CAVS plasma sampl...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064030 | Pride
Human Lc-msms Calcification Aortic valve Fibrosis Sex disparities 
ProteomicsValvular interstitial cells and mesenchymal stem cell proteomes
Proteome profiling of valvular disease driver cell populations and mesenchymal stem cells undergoing osteogenic differentiation.
ORGANISM(S): Homo sapiens (Human) 
2024-01-25 | PXD029949 | Pride
Calcific aortic valve disease Human vics 
ProteomicsLPA-TriCEPS crosslinked to human VICs
We used ligand-receptor capture mass spectrometry that identified major facilitator superfamily domain containing 5 (MFSD5) as a previously unreported Lp(a) receptor.
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD026861 | Pride
Mfsd5 Mass spectrometry Valve interstitial cells 
ProteomicsSortilin Drives Valvular Interstitial Cells to a Combined Inflammatory Myofibroblast-Osteogenic Phenotype in Calcific Aortic Valve Disease as Revealed by Single-cell Analysis
Background: Calcific aortic valve disease (CAVD), the most common valve disease is comprised of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology of CAVD, and its role in the transformation of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD038117 | Pride
Calcification Aortic stenosis Sortilin Inflammation Single-cell rna sequencing Fibrosis 
ProteomicsIntegration of functional imaging, cytometry and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
Human Mitral valve (mv) Proteomic Ischemic mitral regurgitation (imr) Echocardiography Endothelial-to-mesenchymal transition (endmt) Histo-cytometry 
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