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ProteomicsAn evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics
Objective: ADP-ribosylation is a post-translational modification that plays an important role in cellular processes. Our previous work implemented multiple gas-phase separation strategies (e.g., FAIMS) and in-source CID on the quadrupole-Orbitrap (Exploris 480) to increase the yield and acceptor sit...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD067389 | Pride
Macrophage Proteomics Ethcd Hcd Adp-ribosylation 
ProteomicsA Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-gamma
Mass spectrometry-enabled ADP-ribosylation workflows are developing rapidly, providing researchers a variety of ADP-ribosylome enrichment strategies and mass spectrometric acquisition options. Despite the growth spurt in upstream technologies, systematic ADP-ribosyl (ADPr) peptide mass spectral anno...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD027454 | Pride
Ifn-gamma Spleen Software Liver Adp-ribosylation Lc-ms/ms 
ProteomicsNanoparticle-enabled plasma proteomics of a preclinical atherosclerosis model reveals common signatures with human disease
Coronary heart disease (CHD) accounts for one-third of deaths in the United States, with an annual economic burden exceeding $400 billion. Elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for CHD, through its promotion of atherosclerosis. Mutations in the ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD063218 | Pride
Plasma Atherosclerosis Dia Nanoparticle Proteomics 
ProteomicsContext-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation
Abstract: The role of pro-inflammatory macrophage activation in cardiovascular disease (CVD) is a complex one amenable to network approaches. While an indispensible tool for elucidating the molecular underpinnings of complex diseases including CVD, the interactome is limited in its utility as it is ...
ORGANISM(S): Homo sapiens (Human) 
2020-08-18 | PXD020942 | Pride
Tmt Macrophages Thp-1 cells 
ProteomicsA combined gas phase separation strategy for ADP-ribosylated peptides
ADP-ribosylation (ADPr) is a posttranslational modification that is best studied using mass spectrometry. Method developments that are permissive to low inputs or baseline levels of protein ribosylation represent the next frontier in the field. High-field asymmetric waveform ion mobility spectrometr...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD040898 | Pride
Mono-adp-ribose Gas-phase segmentation Ribosylation High field asymmetric waveform ion mobility spectrometry Gas-phase fragmentation 
ProteomicsMouse and human abdominal aneurysm proteomics
Aortic tissues of developing and established aneurysms produced by angiotensin II (AngII) infusion were examined in Apoe-/- and Ldlr-/- mice. Aortas were also acquired from wildtype C57BL/6J mice following intraluminal elastase incubation. Aortas were dissected free and separated into eight anatom...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-02 | PXD032293 | Pride
Fermt3 Co-regulation Mass spectrometry 
ProteomicsImpact of variations in standard operating procedure on plasma proteome recovery
Advancements in mass spectrometry and complementary technologies now enable comprehensive and high-resolution plasma proteomics. Plasma is a key biofluid for clinical research, harboring potential disease informative biomarkers. Commercial sources of non-diseased, healthy donor plasma samples are of...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD069212 | Pride
Mass spectrometry Clinical proteomics Biofluids Data-independent acquisition 
ProteomicsRole of lncRNA-SPANXA2-OT1 in macrophage chemotaxis
Coronary artery disease (CAD) remains the leading cause of mortality worldwide. Macrophages play a crucial role in recruiting immune cells and regulating the inflammatory milieu through the release of a diverse array of cytokines, chemokines, and other immune mediators in CAD. Long noncoding RNAs (l...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD059474 | Pride
Lc-msms Human primary macrophage Coronary artery disease Long noncoding rna Inflammation 
ProteomicsAn evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics
Objective: ADP-ribosylation is a post-translational modification that plays an important role in cellular processes. Our previous work implemented multiple gas-phase separation strategies (e.g., FAIMS) and in-source CID on the quadrupole-Orbitrap (Exploris 480) to increase the yield and acceptor sit...
ORGANISM(S): Homo sapiens (Human) 
2025-12-26 | PXD068570 | Pride
ProteomicsNuclear RSK1 mediates interferon γ-induced pro-inflammatory activation in human primary macrophages and humanized mice
Pro-inflammatory activation of macrophages promotes various inflammatory disorders. The molecular mechanisms underlying macrophage activation, particularly in the context of nuclear translocation of pro-inflammatory response mediators, remain obscure. We have used a systems approach to explore key r...
ORGANISM(S): Homo sapiens (Human) 
2026-07-08 | PXD069750 | Pride
Pbmc Rsk1 Macrophage Humanized mice Ifng 
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