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Coronary heart disease (CHD) accounts for one-third of deaths in the United States, with an annual economic burden exceeding $400 billion. Elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for CHD, through its promotion of atherosclerosis. Mutations in the ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD063218 | Pride
A current paradigm states that monocytes circulate freely and patrol blood vessels, but differentiate irreversibly into dendritic cells or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The re...
ORGANISM(S): Mus musculus 
While aging is well established as an important risk factor for the development and progression of atherosclerosis, the underlying molecular mechanisms of this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. We investigated the response of bone marrow-deriv...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054290 | Pride
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