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UnknownALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.
Not available
S-EPMC5789956 | biostudies-literature
UnknownInconspicuous breeding coloration to conceal eggs during mouthbrooding in male cardinalfish.
Not available
S-EPMC11700633 | biostudies-literature
UnknownMechanism for the activation of the anaplastic lymphoma kinase receptor.
Not available
S-EPMC8639797 | biostudies-literature
ProteomicsBioID-screening identifies PEAK1 and SHP2 as components of the Alk “proximitome” in neuroblastoma cells
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that is mutated in approximately 10% of pediatric cancer neuroblastoma (NB). To shed light on ALK-driven signaling processes, we employed BioID-based in vivo proximity labeling to identify molecules that interact with ALK. NB cells...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD025208 | Pride
Shp099 Lorlatinib Rmc-4550 Bira* Signaling 
ProteomicsProteomics and phosphoproteomics on NB1 and IMR32 neuroblastoma cells stimulated with ALAKAL2
High-risk neuroblastoma (NB) is notoriously difficult to treat and is responsible for a disproportionate number of childhood deaths due to cancer. One long accepted indicator of high-risk NB and poor prognosis is amplification of the neural MYC (MYCN) oncogene, which is currently therapeutically int...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD021792 | Pride
Neuroblastoma Cancer Nb Tmt Anaplastic lymphoma kinase Phosphorylation Alkal2 Tandem mass tag Alk 
ProteomicsALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
High-risk neuroblastoma (NB) currently presents significant clinical challenges. MYCN and ALK, which are often involved in high-risk NB, lead to increased replication stress in cancer cells, providing options for therapeutic exploitation. We previously identified an ATR/ALK inhibitor combination as ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-13 | PXD041824 | Pride
Alk Atr Elimusertib Neuroblastoma Lorlatinib Alkal Ddr Ceralasertib 
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