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ProteomicsSynergistic interactions between Australian propolis and Doxorubicin against the MCF-7 breast adenocarcinoma cells: Multiomics study understanding the molecular mechanisms of action
The combination of natural products with standard chemotherapeutic agents offers a promising strategy to enhance the efficacy of standard chemotherapy by reducing their dosage and side effects. The standard chemotherapeutic drug for breast and other cancer types- doxorubicin(DOX), also known as Adri...
ORGANISM(S): Homo sapiens (Human) 
2021-07-26 | PXD026331 | Pride
Propolis Breast cancer Metabolomics Proteomics Doxorubicin Mcf-7 Synergy 
ProteomicsRobotic Handling Preserves Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells Differentiation using a Weekend-free, Automatable, Low-variability, Low-cost (WALL) Protocol
As tissue engineering and high-throughput disease modeling develop further, necessitating large quantities of viable cells, automation will be essential. Robotic liquid handling systems are increasingly employed for generating large quantities of induced pluripotent stem cell (iPSC)-derived cells, w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD070184 | Pride
High-throughput Vascular smooth muscle cells Tissue engineering Liquid handling robotics Proteomics Induced pluripotent stem cells Drug screening 
ProteomicsShotgun proteomic elucidation of Synergistic mechanisms of Cannabidiol and SN-38 in the MCF7 cells
We evaluted the synergyistic interactions of cannabidiol (CBD) with standard chemotherapeutic agents such as Docetaxel (DOC), doxorubicin (DOX), paclitaxel (PTX), vinorelbine (VIN), and 7-Ethyl-10-hydroxycamptothecin (SN38) in MCf7 cells ultising different synergy metrics. Then we explored the syner...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026587 | Pride
Breast cancer Proteomics Mcf7 Synergy Cannabidiol Sn-38 Cbd 7-ethyl-10-hydroxycamptothecin 
ProteomicsProteomics Decipher the Molecular Mechanisms of the Herbal Formula Jing Guan Fang in Suppressing Macrophage-Mediated Inflammation.
In this study, we first performed a deep metabolomic profiling of the JGF aqueous extract to create a detailed phytochemical inventory. We then utilized a classic in vitro model of inflammation—lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages—to validate the formula's anti-inflammatory prop...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-14 | PXD066295 | Pride
Proteomics Jgf Inflammation Cytokine storm 
ProteomicsThe post-biotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cell
This research explores the antiproliferative effects of short-chain fatty acid (SCFA) salts (magnesium acetate, sodium propionate, and sodium butyrate) on AGS gastric adenocarcinoma cells. Sodium butyrate (NaB) exhibited the most significant inhibitory impact. The study investigated synergistic inte...
ORGANISM(S): Homo sapiens (Human) 
2024-02-21 | PXD048617 | Pride
Gastric cancer Proteomics Postbiotics Sodium butyrate Dexamethasone Synergy 
ProteomicsShort-chain fatty acids synergistically interact with doxorubicin against gastric adenocarcinoma cells
Short-chain fatty acids (SCFAs) are microbial metabolites, also known as postbiotics, produced by the gut microbiotame, playing essential rolesessential in maintaining gut health and exerting potential anticancer effects. This study investigates the antiproliferative effects of short-chain fatty aci...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD061824 | Pride
Postbiotics Apoptosis Doxorubicin Proteomics Gastric cancer 
ProteomicsInvestigating the multi-mechanistic anticancer effects of 4-bisarylurea thiouracil derivatives in breast cancer cells
The study reports the synthesis of a series of 4-bisarylureathiouracil derivatives (6a-e) for potential use in breast cancer treatment. In vitro cytotoxicity was assessed in MCF-7 and MDA-MB-231 human breast cancer cell lines, revealing significant anti-cancer activity. Compound 6e exhibited the hig...
ORGANISM(S): Homo sapiens (Human) 
2025-07-19 | PXD065576 | Pride
Apoptosis Anti-inflammatory Breast cancer Cytotoxicity Proteomics 
ProteomicsEffect of a functional dairy powder and its major components on the growth of pathogenic and probiotic gut bacteria and the Human Coronavirus 229E
Milk, renowned for its nutritional value, harbours bioactive compounds, including lactoferrin (Lf) [1], immunoglobulins, and functional proteins suggesting broader functionalities beyond nutrition. Lf, an iron glycoprotein, exhibits antimicrobial properties against bacteria, fungi, and viruses."In"t...
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD052339 | Pride
Probiotic Antibacterial In vitro digestion Human coronavirus 229e Antifungal Anti-inflammatory Functional milk product Proteomics Gut bacteria 
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