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ProteomicsThe Leucegene AML surfaceome atlas: immunotherapeutic target identification in AML
We exploited the extensive genomic diversity of the Leucegene cohort of primary human AML specimens to provide an overview of the human AML surfaceome. Due to high cell number requirements, surface proteomics has been underexploited in AML so far, although surface proteome analysis of AML cell lines...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD043772 | Pride
Acute myeloid leukemia Surfaceome Pan-aml antigens 
GenomicsImmunotherapeutic targeting of surfaceome heterogeneity in AML
Immunotherapeutic targeting of surfaceome heterogeneity in AML
PRJNA1010863 | ENA
TranscriptomicsImmunotherapeutic targeting of surfaceome heterogeneity in AML
Immunotherapy remains underexploited in AML compared to other hematological malignancies. Currently, gemtuzumab ozogamicin is the only therapeutic antibody approved for this disease. To identify potential targets for immunotherapeutic intervention, we analyzed the surface proteome of 100 genetically...
ORGANISM(S): Homo sapiens 
2024-05-21 | GSE241989 | GEO
ProteomicsThe Leucegene AML surfaceome atlas: immunotherapeutic target identification in AML
We exploited the extensive genomic diversity of the Leucegene cohort of primary human AML specimens to provide an overview of the human AML surfaceome. Due to high cell number requirements, surface proteomics has been underexploited in AML so far, although surface proteome analysis of AML cell lines...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044480 | Pride
Faims Acute myeloid leukemia Tmt Proteome 
ProteomicsGeneration of Nomo-1 cell surfaceome database
The goal was to build a custom proteome database for cell surface proteins of Nomo-1 (AML cell line). Such custom database was meant to facilitate cross-linking (XL-MS) of cell surface proteins for this cell line using non-cleavable cross-linkers. Using such custom database helps with the computatio...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035404 | Pride
Aml and cell surfaceome Nomo-1 
ProteomicsAn Informatic Approach to Chimeric Antigen Receptor Discovery Integrates Proteomics and Transcriptomics to Identify Novel Combinatorial Pairs
Chimeric antigen receptor (CAR) therapy targeting CD19 yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for over-expressed molecules with potentially tolerable systemic expressio...
ORGANISM(S): Homo sapiens (Human) 
2017-10-24 | PXD007552 | Pride
Tf Thpi Monomac Kasumi Human aml cell lines lc-msms Molm13 09aml 
UnknownIntegrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML.
Not available
S-EPMC7025434 | biostudies-literature
UnknownIntegrated multiomic approach for identification of novel immunotherapeutic targets in AML.
Not available
S-EPMC9185890 | biostudies-literature
ProteomicsStructural surfaceomics of Nomo-1 using PhoX cross-linker with timsTOF
The project aimed to profile the cell surface proteins of Nomo-1 (AML cell line) using structural surfaceomics for identification of protein conformation-based cancer antigens thereby expanding the toolkit for cancer target discovery for immunotherapeutic targeting. To achieve the goal, cell surface...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035591 | Pride
Xl-ms Phox Cell surfaceome Nomo-1 Aml 
ProteomicsStructural surfaceomics of Nomo-1 using DSSO cross-linker with MS3 approach
The project aimed to profile the cell surface proteins of Nomo-1 (AML cell line) using structural surfaceomics for identification of protein conformation-based cancer antigens thereby expanding the toolkit for cancer target discovery for immunotherapeutic targeting. To achieve the goal, cell surface...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035589 | Pride
Ms3 Dsso Xl-ms Cell surfaceome Nomo-1 Aml 
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