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MetabolomicsDietary carbohydrate and protein levels affect the growth performance of juvenile peanut worm (Sipunculus nudus): an LC–MS-based metabolomics study
The peanut worm (Sipunculus nudus) is an economically important fishery resource in China. To determine how dietary carbohydrate and protein levels affects the growth performance of juvenile S. nudus and identify the mechanisms underlying observedpatterns, five isoenergetic and isolipidic diets with...
2021-07-16 | MTBLS2887 | MetaboLights
ProteomicsDeep proteomic and phosphoproteomic profiling of neuroblastoma treated with XPO1 inhibitor Selinexor
Neuroblastoma accounts for 15% of cancer-related deaths in children, highlighting an unmet need for novel therapies. Selinexor is a small molecule inhibitor of XPO1 that shuffles cargo proteins with a nuclear export sequence, many of which are essential for cancer growth and cell maintenance, from t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026454 | Pride
Tmtpro Phosphoproteome Selinexor Xpo1 Neuroblastoma Proteome 
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
MetabolomicsEcological adaptation and succession of human fecal microbial communities in an automated in vitro fermentation system
Longitudinal studies of gut microbiota following specific interventions are vital for understanding how they influence host health. However, robust longitudinal sampling of gut microbial communities is a major challenge, which can be addressed using in vitro fermenters hosting complex microbial comm...
2021-07-15 | MTBLS2531 | MetaboLights
UnknownIdentification of Alkaloids from Corydalisyanhusuo W. T. Wang as Dopamine D₁ Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay.
Not available
S-EPMC6222624 | biostudies-literature
MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
UnknownCytotoxicity-guided isolation of elatostemanosides I-VI from <i>Elatostema tenuicaudatum</i> W. T. Wang and their cytotoxic activities.
Not available
S-EPMC11970508 | biostudies-literature
ProteomicsDeep proteomic and phosphoproteomic profiling of DIPG responses to radiation therapy
Different DIPG tumor models have different responses to radiation therapy, which can be identified by quantitative proteomics/phospho-proteomics approach
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD028285 | Pride
Cancer Radiation therapy Phosphoproteome Dipg Proteome 
UnknownPrediction Analysis of Integrative Quality Zones for <i>Corydalis yanhusuo</i> W. T. Wang Under Climate Change: A Rare Medicinal Plant Endemic to China.
Not available
S-EPMC12383410 | biostudies-literature
ProteomicsHaemaphysalis longicornis salivary gland LC-MSMS
Ticks are notorious carriers of pathogens; these blood-sucking arthropods can spread a variety of deadly diseases. The salivary gland is the main organ in ticks, and this organ begins to develop rapidly when Ixodidae ticks suck blood. When these ticks reach a critical weight, the salivary glands sto...
ORGANISM(S): Haemaphysalis longicornis 
2020-05-26 | PXD013678 | Pride
Salivary gland Haemaphysalis longicornis Lc-msms 
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