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ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
UnknownPreliminary results of a phase II trial of proton radiotherapy for pediatric rhabdomyosarcoma.
Not available
S-EPMC4226806 | biostudies-literature
TranscriptomicsRNA-seq from human patient derived xenografts from pancreatic adenocarcinoma patients: RS10
RNA-seq from human PDX derived from radiographically resectable pancreatic adenocarcinoma patients. All surgically resected tumors were obtained after written patient consent and according to the institutional review board-approved protocols of the University of Texas M.D. Anderson Cancer Center.
ORGANISM(S): Homo sapiens 
2021-09-06 | E-MTAB-10116 | biostudies-arrayexpress
ProteomicsDeglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be non-enzymatically driven by glutaryl-CoA. In mam...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-21 | PXD018156 | Pride
Gcdh Sirt5 Sirtuins Mitochondria Acylation 
TranscriptomicsTranscription profiling time series of Bacillus anthracis growing inside murine macrophages
This experiment follows gene expression within B. anthracis while the bacteria are growing inside murine macrophages, from 1-6 hours post-infection.
ORGANISM(S): Bacillus anthracis 
2007-05-11 | E-MEXP-1036 | biostudies-arrayexpress
UnknownPhase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma.
Not available
S-EPMC5455685 | biostudies-literature
UnknownPhase II Study of Two Weeks on, One Week off Sunitinib Scheduling in Patients With Metastatic Renal Cell Carcinoma.
Not available
S-EPMC6804828 | biostudies-literature
ProteomicsProteogenomic analysis in hibernating mammal suggests contribution of skeletal muscle physiology to hibernation phenotype
Mammalian hibernation is a strategy employed by many species to survive fluctuations in resource availability and environmental conditions. Hibernating mammals endure conditions of dramatically depressed heart rate, body temperature, and oxygen consumption; yet show no typical pathological response...
ORGANISM(S): Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) 
2018-07-11 | PXD003188 | Pride
Amp –deaminsase 1 Proteomics Itraq Skeletal muscle Fibromodulin Galaxy-p Hibernation 
UnknownHominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation.
Not available
S-EPMC10063665 | biostudies-literature
UnknownMotion corrected fetal body magnetic resonance imaging provides reliable 3D lung volumes in normal and abnormal fetuses.
Not available
S-EPMC9310761 | biostudies-literature
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