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TranscriptomicsAnalysis of colorectal tissue from APC- and MYH-associated polyposis patients
Expression profiling is a well established tool for the genome-wide analysis of the transcriptional activity of human neoplasia. However, the high sensitivity of this approach combined with the well-known cellular and molecular heterogeneity of cancer often result in extremely complex and extended e...
ORGANISM(S): Homo sapiens 
2008-04-01 | E-GEOD-9689 | biostudies-arrayexpress
TranscriptomicsThe impact of P53 loss on transcriptome changes following loss of Apc in the intestine
BACKGROUND: p53 is an important tumor suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of thes...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-70262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recom...
ORGANISM(S): Mus musculus 
2006-03-13 | E-TABM-81 | biostudies-arrayexpress
ProteomicsQuantitative proteomics in G1 cells reveals the insulin receptor adaptor IRS2 as an APC/CCdh1 substrate
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that controls progression through the eukaryotic cell cycle by targeting key substrates for degradation through the ubiquitin proteasome pathway. During G1, the APC/C works in concert with its co-activator Cdh1 to recognize and u...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD018329 | Pride
Tmt Human Irs2 Apc substrate 
TranscriptomicsPhenotype modulation of VSMCs on patterned substrate
Loss of contractility and acquisition of an epithelial phenotype of vascular smooth muscle cells (VSMCs) are key events in proliferative vascular pathologies such as atherosclerosis and post-angioplastic restenosis. There is no proper cell culture system allowing VSMC differentiation so that it is d...
ORGANISM(S): Rattus norvegicus 
2013-11-14 | E-MTAB-1888 | biostudies-arrayexpress
Transcriptomicsapc derived mp in vitro
Background-The endothelial protein C receptor (EPCR) plays an important role within the protein C (PC) pathway in regulating coagulation and inflammation. Recently, we described a novel mechanism of EPCR release from the surface of primary physiological cells. Induced by exogenous activated protein...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-5660 | biostudies-arrayexpress
ProteomicsThe ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations have found that OGT levels oscillate during the cell division process. Specifically, OGT abundance is downregulated during mitosis, but...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050552 | Pride
Uterine carcinoma Ubiquitination Cell cycle Ogt Apc/ccdc20 
UnknownHow APC/C-Cdc20 changes its substrate specificity in mitosis.
Not available
S-EPMC3059483 | biostudies-literature
TranscriptomicsAnalysis of Mouse Dendritic and Antigen presenting cell and Mouse autoimmune and Inflammatory Response
Antigen presenting cells (APC) express receptors recognizing microbes and regulating immune responses by binding to corresponding ligands on immune cells. Having discovered a novel inhibitory pathway triggered by ligation of DC-HIL on APC to a heparin/heparan sulfate-like saccharide of syndecan-4 o...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17699 | biostudies-arrayexpress
ProteomicsParadoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
The Anaphase Promoting Complex/Cyclosome (APC/C) is a mega-dalton ubiquitin ligase that initiates mitotic exit by targeting substrates for degradation. The APC/C is activated by Cdc20, which acts as a substrate receptor, and is inhibited by the mitotic checkpoint complex (MCC), which delays mitoti...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD013786 | Pride
Cdc20 Mitosis Apcin 
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