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ProteomicsSUZ12 immunoprecipitation followed by PRM of SUZ12 peptides to identify alternatively spliced isoforms of SUZ12 at the protein level.
Alternative splicing of SUZ12 exon 4 is predicted to generate two alternative isoforms differing by the inclusion or exclusion of 69 nucleotides in exon 4, which we named SUZ12-long (SUZ12-L) and SUZ12-short (SUZ12-S) respectively. At the protein level SUZ12 exon 4 encodes 23 amino acids (aa 129–152...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046742 | Pride
Exon As Ip Prc2 Mescs Alternative splicing Prm. Escs Suz12 Polycomb 
ProteomicsSUZ12 immunoprecipitation followed by protein indentification via mass spectrometry (SUZ12 IP-MS) in mESCs of SUZ12 WT, delta exon 4, KO, and KO rescues with SUZ12-L and SUZ12-S
Suz12 exon 4 encodes 23 amino acids (aa 129–152 in SUZ12-L) that partially overlap with the WD-binding domain 1 (WDB1, 110–145). We reasoned that exon 4 skipping might alter the structure of SUZ12 and, possibly, PRC2 composition. To explore this possibility, we generated ESCs that lack the Suz12 exo...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046660 | Pride
Flag-tag Rescues Ko Ip Prc2 Interactions Mescs Escs Suz12 Polycomb 
ProteomicsHistone post translational modification mass sprectrometry SUZ12 exon 4 cell lines
We investigate the contribution of each SUZ12 isoform on PRC2 activity on chromatin using our different ESC lines. As an additional comparison for ∆ex4 cells (SUZ12-S), we included an ESC clone in which an unsuccessful CRISPR editing event resulted in a mutant allele with nearly constitutive splicin...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046640 | Pride
Ptms Ko Histones Prc2 Mescs Escs Suz12 Dda Polycomb 
UnknownCase report: Twice-daily tolvaptan dosing regimen in a challenging case of hyponatremia due to SIAD.
Not available
S-EPMC10822982 | biostudies-literature
UnknownAdjuvant CDK4/6 Inhibitors for Early Breast Cancer: How to Choose Wisely?
Not available
S-EPMC10881905 | biostudies-literature
TranscriptomicsPRO-seq in control and H3.3 K4A mutant mESCs
Study to investigate the role of histone residues H3K4 and H3K36 for gene expression, histone localization and neuronal lineage specification by mutation of K4 and K36 in H3.3 to alanine. Histone variant H3.3 differs from the canonical H3.1/H3.2 by only 4 to 5 amino acids, which are necessary for n...
ORGANISM(S): Mus musculus 
2020-01-28 | E-MTAB-8617 | biostudies-arrayexpress
UnknownTreatments of Interest in Male Breast Cancer: An Umbrella Review.
Not available
S-EPMC11856642 | biostudies-literature
UnknownImmunotherapy for the Treatment of Cutaneous Squamous Cell Carcinoma.
Not available
S-EPMC8427439 | biostudies-literature
UnknownGender-specific aspects related to type of fertility preservation strategies and access to fertility care.
Not available
S-EPMC7594356 | biostudies-literature
UnknownTemporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients.
Not available
S-EPMC11513697 | biostudies-literature
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