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ProteomicsTotal and phosphoproteome analysis of effects of topoisomerase 1 and ATR inhibitors in small cell lung cancer nuclei
Total and phosphoproteome analysis of effects of topoisomerase 1 (SN-38) and ATR (M1774) inhibitors in small cell lung cancer. Experiments performed in nuclear extract. See MetaData for more information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-21 | MSV000091336 | MassIVE
ProteomicsHuman serine/threonine protein kinase ATR LC-MS/MS
ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engage in antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm are ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031385 | Pride
Biotin modification Cis/trans prolyl isomerization Mass protein footprinting Bh3-like domain Atr 
ProteomicsPhosphoproteomic Analysis of Mec1/ATR Signaling in Response to Different Manners of Kinase Activation
The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we employed a combined genetic-phospho...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD009734 | Pride
Atr Phosphoproteomics Mec1 Dna2 Dpb11 Ddc1 
TranscriptomicsTranscription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants
Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.
ORGANISM(S): Arabidopsis thaliana 
2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress
ProteomicsPhosphoproteomic Datasets for Mec1/ATR signaling in Checkpoint-deficient (rad53Δ) cells
The Mec1/ATR kinase is crucial for genome stability, yet the mechanism by which it prevents gross chromosomal rearrangements (GCRs) remains unknown. Here we find that in cells with deficient Mec1 signaling, GCRs accumulate due to the deregulation of multiple steps in homologous recombination (HR). M...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-05 | PXD051892 | Pride
Mec1/atr Saccharomyces cerevisiae (baker's yeast) Dna damage checkpoint 
TranscriptomicsDNA replication and DSB factor binding in the meiotic S-phase checkpoint in budding yeast
During gamete formation, crossover recombination must occur on replicated DNA to ensure proper chromosome segregation in the first meiotic division. We identified a Mec1/ATR-dependent replication checkpoint in budding yeast that prevented the earliest stage of recombination, the programmed induction...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-20 | E-GEOD-46841 | biostudies-arrayexpress
GenomicsATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
ATR kinase inhibitors induce mitochondrial fission in CD8+ T cells and impair immune memory in vivo
PRJNA1469593 | ENA
ProteomicsThe phosphoproteomics study of Chk1 and ATR inhibitors regulation on cells
Ataxia Telangiectasia and Rad3-related (ATR) and Checkpoint Kinase 1 (Chk1) are crucial kinases in the DNA Damage Response (DDR) pathway. While the roles of ATR and Chk1 within the DDR are well-established, their roles in mitosis are not fully understood. Here, we describe that the ATR-Chk1 pathway ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD058541 | Pride
Phosphoproteomics Cdk1 Inhibitor Chk1 
TranscriptomicsTranscription profiling of human fibroblasts subjected to DNA damage reveals ATM-dependent regulation of gene expression
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6971 | biostudies-arrayexpress
TranscriptomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-14761 | biostudies-arrayexpress
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