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ProteomicsThe structural basis of the multi-step allosteric activation of Aurora B kinase
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the ...
ORGANISM(S): Xenopus cf. laevis UF 185698 
2023-05-31 | PXD038935 | Pride
Xenopus laevis Hdx-ms Aurora b 
Proteomics15 cm Aurora Gen3 column benchmarking on an Exploris 480
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Homo sapiens (Human) 
2024-02-13 | PXD045457 | Pride
Vanquish neo Orbitrap exploris 480 Trap-and-elute 
ProteomicsAurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics.
Precise regulation of kinetochore-microtubules is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of Aurora B is the N-terminal “tail” domain of Hec1/NDC80, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-28 | PXD006892 | Pride
Human aurora a kinase hec1 
Proteomics293T Flag-Aurora-A Co-IP LC-MSMS
To explore the potential targets of Aurora-A in glycolytic regulation
ORGANISM(S): Homo sapiens (Human) 
2019-11-21 | PXD016110 | Pride
Human Lc-msms 293t Flag-aurora-a co-ip 
TranscriptomicsSelective Targeting of the Proliferating Compartment in Chronic Lymhocytic Leukemia by Inhibition or Downregulation of Aurora Kinases
Chronic lymphocytic leukemia (CLL) B-cells receive signals from the lymph node and bone marrow (BM) microenvironments that regulate their survival and proliferation. These signals and the pathways that propagate them to the interior of the cell represent potential targets for therapeutic interventio...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30896 | biostudies-arrayexpress
ProteomicsProteomics analysis with the Aurora-A PROTAC, JB170
The mitotic kinase Aurora-A is essential for cell cycle progression and considered a priority cancer target. Dozens of ongoing clinical trials are testing the anti-cancer potential of Aurora-A kinase inhibitors. While the catalytic activity of Aurora-A is essential for its function during mitosis, a...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD019585 | Pride
Proteomics analysis with the aurora-a protac Jb170 
ProteomicsAn Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity
Cancer cells are often aneuploid and frequently display elevated rates of chromosome mis-segregation, called chromosomal instability (CIN). CIN is caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduce the correction efficiency of erroneous K-MT attachments. UMK57, a chemical a...
ORGANISM(S): Homo sapiens (Human) 
2025-02-18 | PXD058824 | Pride
Kinase Phosphatase Pp2a Kinetochore Aurora a Bod1l1 
ProteomicsQuantitative proteomics and bioinformatics analyses reveal the mechanism of pan-aurora kinase inhibitor tozasertib in neuroblastoma
Neuroblastoma is the third most common pediatric cancer and is responsible for approximately 15% of all childhood cancer deaths (Maris & Matthay, 1999). In our analysis, we found that poor patient survival with increasing mRNA expression level of AURKA and AURKB in Mycn-amplified neuroblastoma. In t...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-09-30 | PXD007640 | Pride
Neuroblastoma/ tozasertib/ itraq/ metabolite/ aurora kinase inhibitor. 
UnknownAnalyzing insulin samples by size-exclusion chromatography: a column degradation study.
Not available
S-EPMC4359628 | biostudies-literature
ProteomicsIdentification of AURORA A interaction partners
The oncogenic kinase AURORA A is essential for mitotic progression, and its catalytic inhibition arrests cells at the G2/M-transition. Unexpectedly, partial degradation of AURORA A by PROTACs (proteolysis targeting chimeras) induces profound S-phase defects, revealing a non-catalytic scaffolding fun...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD069843 | Pride
Coip Interactome 
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