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UnknownHes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling.
Not available
S-EPMC4299340 | biostudies-literature
ProteomicsAged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling
Increasing evidence suggests that age-related inflammation plays a pivotal role in osteoarthritis (OA) pathogenesis, but the mechanism is not fully understood. Here, we demonstrate that skin aging is an important driver of experimental OA progression in male mice via enhanced IL-36 receptor (IL-36R)...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD062165 | Pride
Aged skin Il-36 receptor antagonist Osteoarthritis Microneedles Senescent keratinocytes 
UnknownRegional myocardial motion in patients with mild cognitive impairment: a pilot study.
Not available
S-EPMC5932804 | biostudies-literature
ProteomicsPlant pathogenic fungi influenced by citric acid
proteomics investigation about the impact of micromolar citric acid on Fusarium graminearum
ORGANISM(S): Fusarium Graminearum Ph-1 
2024-07-03 | PXD053628 |
UnknownRandomized, Noncomparative, Phase II Trial of Early Switch From Docetaxel to Cabazitaxel or Vice Versa, With Integrated Biomarker Analysis, in Men With Chemotherapy-Naive, Metastatic, Castration-Resistant Prostate Cancer.
Not available
S-EPMC5791829 | biostudies-literature
ProteomicsLysine 2-hyroxyisobutyrylome, acetylome and succinylome in prokaryotes
identification of lysine 2-hyroxyisobutyrylome, acetylome and succinylome in prokaryotes
ORGANISM(S): Proteus Mirabilis Atcc 29906 Escherichia Coli 
2019-04-04 | PXD013377 |
ProteomicsHuman HEK293T nuclear extract LC-MSMS
Five tandem-domain reader proteins (BPTF, CBP, TAF1, TRIM24 and TRIM33) were designed and prepared as the enriched probes, and a group of binding proteins from HEK293T were enriched by domain probes and identified by HPLC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD014909 | Pride
Lc-msms Hek293t Nuclear extract 
ProteomicsDNA-guided Photoactivatable Probe-based Chemical Proteomics Reveals the Reader Protein of mRNA Methylation
We report a DNA templated chemistry and photo-crosslinking based method to detect the readers of mRNA modification. By use of N6-methyladenosine (m6A), we illustrated that this method can be successfully utilized for labelling and enriching the readers of mRNA modification, as well as for the discov...
ORGANISM(S): Homo Sapiens 
2020-05-30 | PXD019480 |
ProteomicsSILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD051415 | Pride
Hela Lc-msms Hbo1 Kla 
ProteomicsSILAC experiments profiling of the proteome of WT and CobB KO E.coli
SILAC experiments profiling of the proteome of WT and CobB KO E.coli
ORGANISM(S): Escherichia Coli 
2021-12-11 | PXD030345 |
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