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ProteomicsIdentifying interactors through BioID2 in rat cortical neurons
Utilizing proximity labeling technolgy coupled to LC-MS/MS to identify TTBK1 and TTBK2 unique interactors in rat cortical neurons
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD017937 | Pride
Neurons Proteomics Bioid2 Interactors 
ProteomicsIdentification of TTBK1 autophosphorylation sites in HEK293 cells
Wild type or kinase dead TTBK1 kinase is overexpressed in HEK293 cells, IP and seperated on SDSPAGE gel. TTBK1 corresponding bands are cut and analyzed on shotgun proteomics.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD017939 | Pride
Autophosphorylation site Ttbk1 
ProteomicsTTBK1/TTBK2 Phosphoproteomics in mouse cortical neurons
TTBK1 and TTBK2 unique substrate identifications in mouse cortical neurons through global phosphoproteomics studies. shRNA for both TTBK1 or TTBK2 was used to treat mouse cortical neurons, to knockdown each kinase.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD017938 | Pride
Phosphoproteomics Shrna Neurons Ttbk2 Ttbk1 
ProteomicsIdentification of Aryl Hydrocarbon Receptor (AhR) as a Functional Target that Enhances Astrocytic ApoE Secretion
We discovered a chemical series that enhances ApoE secretion from human astrocytes through mechanisms independent of LXR agonism. Using chemoproteomics, photoaffinity probes, KINOMEscan analysis, and siRNA knockdowns, we identified the aryl hydrocarbon receptor (AhR), a transcription factor not prev...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD071908 | Pride
Target id Lc-ms/ms 
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