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ProteomicsTaphonomy and Negative Results: An Integrated Approach to Ceramic-bound Protein Residue Analysis
Despite the growing body of evidence demonstrating that proteins can survive for thousands to even millions of years in selected contexts, there are relatively few examples of the successful recovery and identification of archaeological protein residues from ceramic artifacts. Claims of positive res...
ORGANISM(S): Bos taurus (Bovine) 
2018-12-24 | PXD009431 | Pride
Taphonomy Lc-ms Archaeological proteins Ceramics 
ProteomicsProximity labelling reveals effects of disease-causing mutations on the DNAJC5/cysteine string protein α interactome
Cysteine string protein α (CSPα), also known as DNAJC5, is a member of the DnaJ/Hsp40 family of co-chaperones. The name derives from a cysteine-rich domain, palmitoylation of which enables localization to intracellular membranes, notably neuronal synaptic vesicles. Mutations in the DNAJC5 gene that ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-01-04 | PXD037258 | Pride
Exocytosis Neuronal ceroid lipofuscinosis Warwick_rtp Miniturbo Snare Pc12 cell Neurodegeneration Stxbp1 
UnknownEnhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers.
Not available
S-EPMC3446404 | biostudies-literature
UnknownBRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance.
Not available
S-EPMC10055590 | biostudies-literature
TranscriptomicsSingle-cell transcriptional landscape of human embryonic limb development
Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common....
ORGANISM(S): Homo sapiens 
2022-04-15 | E-MTAB-8813 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 4 week old BALB/c_Fech m1Pas mice (Fech) vs with 4 week old control BALB/c mice
Comparison of liver gene expression of 4 week old BALB/c_Fech m1Pas mice(Fech mice for short) with 4 week old control BALB/c mice.
ORGANISM(S): Mus musculus 
2005-10-21 | E-MEXP-194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of male Fech mutant BALB/c mouse livers vs male control BALB/c livers
Comparison of gene expression in livers of male Fech mutant BALB/c mouse with livers of male control BALB/c
ORGANISM(S): Mus musculus 
2005-10-14 | E-MEXP-189 | biostudies-arrayexpress
ProteomicsMYC sensitises cells to apoptosis by driving energetic demand
The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sens...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034517 | Pride
Nucleotide catabolism Pentose phosphate pathway Myc Energy Metabolic flux Nucleotide biosynthesis Apoptosis Glutamine Adenylate kinase 
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional landscape of human embryonic limb development - Mouse
To investigate into the evolutionary conversation of the single-cell transcriptome of human fetal limbs, especially the principles of forelimb and hindlimb specification and proximal-distal axis establishment, we collected the forelimbs and hindlimbs of mouse embryos matching human samples. We disse...
ORGANISM(S): Mus musculus 
2022-04-15 | E-MTAB-10514 | biostudies-arrayexpress
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