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ProteomicsCerulenin action on colon cancer cell line
Showing the anti cancer activity of Cerulenin on colon cancer cell lines. The study shows the mechanismm of apoptosis induction as a result of cerulenin treatment to colon cancer cell lines.
ORGANISM(S): Homo sapiens (Human) 
2023-02-05 | PXD023569 | Pride
Orbitrap fusion Human Colon cancer Hct116 Cerulenin Proteomics Cell line Lc-ms/ms 
ProteomicsQuantitative proteomic analaysis of colorectal cancer
Colorectal cancer (CRC) remains among the topmost malignancy across the globe. It stands to be the leading cause of cancer mortality worldwide. It is the second most common cancer diagnosed in women and the third most in men that accounts for approximately 10% of cancers diagnosed annually. It will ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD039285 | Pride
Orbitrap fusion Tmt Tumor tissue Colorectal cancer Lc-ms/ms 
ProteomicsCo-culture CRISPR screens reveal ATG9A as a regulator to macrophage-mediated cytotoxicity in cancer
This study investigates the role of cancer cell surface proteins in modulating the response of cancer cells to macrophage-induced cytotoxicity. Utilizing two targeted CRISPR screens using OVCAR-8 cell line and a targeted CRISPR library for cancer cell surface proteins, ATG9A was identified as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-29 | PXD053872 | Pride
Atg9a  macrophage-mediated cytotoxicity  crispr screens  cancer cell surface proteins 
ProteomicsDiscovery and development of CLL-1 as a cellular immunotherapy target in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive hematologic malignancy with myeloproliferative characteristics that affects young children and is associated with significant morbidity and mortality. Leukemia stem cells (LSCs) have been shown to drive relapse and progression in JMML and incl...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD052910 | Pride
Jmml Surfaceomics Car-t cell Immunotherapy 
ProteomicsGenome-scale CRISPR screens identify PTGES3 as a direct modulator of AR function in advanced prostate cancer
The androgen receptor (AR) is a critical driver of prostate cancer (PCa). To study regulators of AR protein levels and oncogenic activity, we created the first live cell quantitative endogenous AR fluorescent reporters. Leveraging this novel AR reporter, we performed genome-scale CRISPRi flow cytome...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD066297 | Pride
Ar Crispr screens Ptges3 Prostate cancer 
ProteomicsStructural surfaceomics of myeloma models to identify tumor-specific protein conformations
Proteins at the cell surface are promising targets for cancer immunotherapies. While standard surface proteomics can be powerful for target discovery, even more fruitful is identifying cancer-specific surface protein features. To this end, we recently described a technology to identify cancer-specif...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD059495 | Pride
Cell surface proteomics  xl-ms  crosslinking mass spectrometry  structural biology  protein structure 
ProteomicsEssential role of Protein kinase R in the pathogenesis of pulmonary veno-occlusive disease
Pulmonary veno-occlusive disease (PVOD) is a rare and severe form of pulmonary arterial hypertension, characterized by progressive obstruction of small pulmonary vessels and a lack of effective therapeutic options. Our previous research, utilizing a mitomycin C (MMC)-induced rat model, demonstrated ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-11 | PXD066782 | Pride
Protein kinase r Proteomics Pvod 
ProteomicsDetection of mutated peptides of SARS-CoV-2 from COVID-19-infected patients
This project involves the identification of mutated peptides from swab and plasma samples using an in-house developed Mutant Peptide Database (MPD)
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD029300 | Pride
Sars-cov-2 Mass spectrometry Mutant peptides Covid-19 
ProteomicsDe novo lipogenesis as a therapeutic target
Inhibition of the de novo lipogenesis established the connections between the role of the onco-metabolic pathway regulating diverse cell survival processes which suggest targeting these marker enzymes can be of great use in terms of CAC diagnosis, treatment, and further management. In this study we ...
ORGANISM(S): Homo Sapiens 
2025-11-03 | PXD031127 | panorama
ProteomicsProteomic Blueprint of the Pituitary anterior and posterior lobes for better understanding of the physiology of pituitary gland.
This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes.
ORGANISM(S): Homo Sapiens 
2022-12-06 | PXD029991 | panorama
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