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TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54241 | biostudies-arrayexpress
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
ProteomicsM. tuberculosis phoP mutant lacking mcr7
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-08-29 | PXD000698 | Pride
Mycobacterium tuberculosis Maxquant Phop Mcr7 
ProteomicsMass-spectrometry-based analysis of the secretome of M. tuberculosis mutants
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here we study the proteme of various ESX-1 knock-out mutants.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD011466 | Pride
Esx-1 Mycobacterium tuberculosis 
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [RNA-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54240 | biostudies-arrayexpress
ProteomicsSecretome and intracellular proteome of eccE1 and mycP1 deletion mutants of Mycobacterium tuberculosis
Mycobacterium tuberculosis uses the specialised ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for disease progression. ESX-1 is a multi-subunit apparatus with a membrane complex that is predicted to form a pore in the cytoplasmic membrane. In M. tuberc...
ORGANISM(S): Mycobacterium tuberculosis 
2019-12-16 | PXD012584 | Pride
Esx-1 Mycobacterium tuberculosis Ecce1 Mycp1 
ProteomicsespB deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we investigate the effect of espB on the secretion of ESX-1 components and ot...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-09-24 | PXD011475 | Pride
Esx-1 Espb Mycobacterium tuberculosis 
ProteomicsSecretome and intracellular proteome of espB deletion mutant of Mycobacterium tuberculosis
Mycobacterium tuberculosis relies on the ESX-1 secretion system for survival, multiplication in and escape from macrophages. In this work we investigate the role of the EspB protein, encoded within the esx-1 gene cluster, in virulence and ESX-1 substrate secretion in M. tuberculosis H37Rv. Genetic, ...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-09-24 | PXD016565 | Pride
Esx-1 Espb Mycobacterium tuberculosis 
TranscriptomicsGenomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis 18b
Introduction: Tuberculosis (TB) is a serious human disease caused by the bacterium Mycobacterium tuberculosis (Mtb). One third of the world’s population is estimated to be latently infected with Mtb. Exact mechanisms and properties of latent TB infection (LTBI) are not fully elucidated. In essence...
ORGANISM(S): Mycobacterium tuberculosis 
2016-02-17 | E-GEOD-71066 | biostudies-arrayexpress
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