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ProteomicsWnt/β-catenin and NFκB signaling synergize to trigger growth-factor-free regeneration of adult primary human hepatocytes
The liver has a remarkable capacity to regenerate, which is sustained by the ability of hepatocytes to act as facultative stem cells that, while normally quiescent, re-enter the cell cycle upon injury. In rodents, growth factor signaling is indispensable, whereas Wnt/β-catenin is not required for ef...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD036100 | Pride
Growth factors 3d culture. Wnt/β-catenin Liver regeneration Priming 
ProteomicsSelective Modification of Asparagine and Glutamine via Isohypsic Reaction
The selective modification of amino acids within proteins represents the epitome of a chemoselective reaction. Current protein modification techniques are constrained to nucleophilic and redox-active residues, restricting their ability to target amino acids outside this scope. Herein, we introduce t...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2026-05-25 | PXD055899 | Pride
Asparagine Ptm Chemical proteomics Glutamine 
ProteomicsSystem-wide profiling of drug residence time by proteome integral solubility alteration assay
Most drugs used in the clinic and drug candidates target multiple proteins, and thus detailed characterization of their efficacy targets is required. While current methods rely on quantitative measurements at thermodynamic equilibrium, kinetic parameters such as the residence time of a drug on its t...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD034351 | Pride
Target engagement Drug development Thermal proteome profiling. Efficacy target Lead compound optimization Target prioritization Binding affinity Precision medicine Target occupancy 
ProteomicsIon-based Proteome Integrated Solubility Alteration Assay for System-wide Profiling of Protein-Molecule Interactions - full curve data
Unbiased drug target engagement deconvolution and mechanism of action elucidation are major challenges in drug development. Modification-free target engagement methods, such as thermal proteome profiling, have gained increasing popularity over the last several years. However, these methods have limi...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033081 | Pride
Proteomics Mechanism of action Drug target deconvolution Thermal protein profiling Cancer 
ProteomicsIon-based Proteome Integrated Solubility Alteration Assay for System-wide Profiling of Protein-Molecule Interactions
Unbiased drug target engagement deconvolution and mechanism of action elucidation are major challenges in drug development. Modification-free target engagement methods, such as thermal proteome profiling, have gained increasing popularity over the last several years. However, these methods have limi...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD030695 | Pride
Proteomics Mechanism of action Drug target deconvolution Thermal protein profiling Cancer 
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD060423 | Pride
Thioredoxin reductase 1 (trxr1) Nrf2 Immune response Treg B16f10 Auranofin 
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD069997 | Pride
Mouse model Treg Auranofin 
ProteomicsA peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signa...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-15 | PXD034792 | Pride
Autoimmune arthritis Arthritis Antigen-specific t cells Vaccine 
ProteomicsBone marrow-selected antigen specific regulatory B cells
Autoimmunity is often regarded as pathogenic, but this view has gradually shifted over time. Based on insights from thymus selection, T cells are now known to be selected by self-antigens and positive selection in the thymus medulla leads to regulatory functions. B cells are selected in the bone mar...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-13 | PXD025837 | Pride
Breg Lc-ms/ms Facs Mouse 
ProteomicsA novel non-galactosylated tolerogenic antigen-specific vaccine protects against arthritis via VISTA-expressing regulatory T cells in DRB1*04:01 mice
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, cartilage damage and bone erosion. Despite improvements with the introduction of biological disease-modifying anti-rheumatic drugs (DMARDs), RA remains incurable. Advancements in peptide-based vaccination...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD056818 | Pride
Vaccine Arthritis Mice Immune cells 
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