Sort   by:  
 Page size 
TranscriptomicsElectron acceptor-dependent identification of key anaerobic toluene degraders at a tar-oil contaminated aquifer by Pyro-SIP
Bioavailability of electron acceptors is probably the most limiting factor in the restoration of anoxic, contaminated environments. The oxidation of contaminants such as aromatic hydrocarbons, particularly in aquifers, often depends on the reduction of ferric iron or sulphate. We have previously det...
ORGANISM(S): unidentified 
2011-03-18 | E-GEOD-25449 | biostudies-arrayexpress
ProteomicsGlycan-based Biological Degraders Targeting the Cytokine Immune Axis
The project investigates targeted degradation of IL-6 and sIL6-R using bispecific Biological Degraders (BioDegs) that enable receptor-mediated uptake via the asialoglycoprotein receptor (ASGPR). Various IL-6(R)–binding scaffolds were modified with triantennary N-acetylgalactosamine (TGN) to promote ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD075514 | Pride
Asgpr Targeted protein degradation Biological degraders Tri-n-acetylgalactosamine Lysosomal degradation Il-6 Sil-6r 
ProteomicsDistinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders
CDK4/6 inhibitors (CDK4/6i) are effective in metastatic breast cancer, but they have been only modestly effective in most other tumor types. Here we show that tumors expressing low CDK6 rely on CDK4 function, and are exquisitely sensitive to CDK4/6i. In contrast, tumor cells expressing both CDK4 and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023137 | Pride
Cdk4/6 inhibitors and degraders Cdk6 complex Tumor 
UnknownDesign, Synthesis, and Biological Evaluation of Selective TBL1X Degraders.
Not available
S-EPMC11472461 | biostudies-literature
UnknownFunctional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Not available
S-EPMC7614256 | biostudies-literature
UnknownDesign principles for cyclin K molecular glue degraders.
Not available
S-EPMC10746543 | biostudies-literature
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
UnknownCatalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
Not available
S-EPMC11827123 | biostudies-literature
UnknownDesign, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders.
Not available
S-EPMC8819633 | biostudies-literature
UnknownProgramming inactive RNA-binding small molecules into bioactive degraders.
Not available
S-EPMC10232370 | biostudies-literature
Sort   by:  
 Page size