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ProteomicsIdentification of the Tau aggresome in progressive supranuclear palsy by in situ biotinylation by antibody recognition
Here, we used an unbiased proteomic approach, which combines antibody-mediated proximity-detection of co-aggregated proteins together with mass spectrometry. Biotinylation by antibody recognition (BAR) is a recently developed method, by which a primary antibody recognises the target of interest in f...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD028237 | Pride
Tauopathy  aggresome  biotinylation 
ProteomicsBiotinylation by antibody recognition - A novel method for proximity labeling
Identification of protein-protein interactions is a major goal of biological research. Despite technical advances over the last two decades, important but still largely unsolved challenges include the high-throughput detection of interactions directly from primary tissue and the identification of in...
ORGANISM(S): Homo sapiens (Human) 
2017-10-17 | PXD004736 | Pride
Lmna biotin proximiy labeling 
ProteomicsIn Situ Proximity Labeling Identifies Lewy Pathology Molecular Interactions in the Human Brain
The intracellular misfolding and accumulation of alpha-synuclein into structures collectively called LP is a central phenomenon for the pathogenesis of synucleinopathies including Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Understanding the molecular architecture of LP is crucial ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD028830 | Pride
In situ Biotinylation by antigen recognition Neuropathology Lewy pathology Alpha-synuclein 
ProteomicsIdentification of the Tau aggresome in progressive supranuclear palsy by in situ biotinylation by antibody recognition reveals protein networks involved in energy metabolism, cytoskeletal dynamics and protein degradation systems.
Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease defined pathologically by the presence of insoluble phosphorylated-Tau (p-Tau) in neurons and glia. Identifying co-aggregating proteins within p-Tau inclusions reveals important insights into processes affected by the agg...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD028770 | Pride
Tauopathy  aggresome  biotinylation 
ProteomicsA novel mechanism for NF-kB activation via IkB aggregation
Proteins which interact with IkBa in insoluble aggregates known as Mallory-Denk bodies were characterized by AP-MS, Biotinylation by antibody recognition (BAR), and LCMS analysis of detergent solubalized aggregates. See the supplementary table (S12) for file annotation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-31 | MSV000086042 | MassIVE
UnknownBiotinylation by antibody recognition-a method for proximity labeling.
Not available
S-EPMC5790613 | biostudies-literature
GenomicsHomo sapiens strain:HeLa cell
Biotinylation RNA-seq of HeLa cell
PRJNA1014249 | ENA
ProteomicsPlxnA2 interactome in primary hippocampal murine neurons
Proper assembly of complex neural circuits requires the coordinated action of a limited set of axon guidance molecules, including plexins. To probe the extracellular vicinity of PlxnA2 in primary hippocampal neurons, we used in this work antibody directed proximity biotinylation and identified cand...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD060323 | Pride
Biotinylation by antibody recognition Bar. Proximity labelling Plxna2 
ProteomicsDoes alpha synuclein strain or GCase enzyme activity drive clinical aggression in GBA-PD?
Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear reasons, PD patients with certain GBA mutations (GBA-PD) have a more aggressive clinical progression. Two testable hypotheses ...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-22 | PXD045437 | Pride
Parkinson's disease Biotinylation by antibody recognition Preformed fibrils Gba1 
ProteomicsExploring the Spatial Landscape of the Estrogen Receptor Proximal Proteome With Antibody-Based Proximity Labeling
Estrogen Receptor-α (ERα) plays a crucial role in breast cancer, driving the transcription of genes involved in tumor progression. The ERα function is dependent on multiple protein-protein interactions (PPIs). As a result of rapid tumor adaptation, these are often altered by drug treatments and acqu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD043294 | Pride
Estrogen receptor Endocrine resistance Bar Interactome 
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