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ProteomicsComparative proteomics of paired human vocal fold and oral mucosa tissue
This dataset brief is about the descriptive proteomic comparison of human oral mucosa and vocal fold tissues by high-resolution mass spectrometry (CID-MS/MS). The vast majority of voice disorders is associated with changes of the unique but delicate tissue of the human vocal folds, wheras the abili...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD025519 | Pride
Oral mucosa Comparative proteomics Human tissue Vocal folds 
ProteomicsOlfactory cleft proteome does not reflect olfactory performance in patients with idiopathic and postinfectious olfactory disorder: A pilot study.
The pathophysiology of post-infectious and idiopathic olfactory loss is still poorly delineated. Since proteins are key players in olfaction and technical advances including LC-MS/MS mass spectrometry give us the opportunity for detailed analysis of the nasal mucus proteome we aimed to undertake a c...
ORGANISM(S): Homo sapiens (Human) 
2018-12-10 | PXD009172 | Pride
Human Olfactory cleft Idiopathic and postinfectious olfactory disorder Lc-ms/ms 
ProteomicsMCM proteins are up-regulated in placentas of women with reduced insulin sensitivity
In the first trimester of pregnancy the human placenta grows rapidly, making it sensitive to changes in the intrauterine environment. To test whether exposure to an environment in utero often associated with obesity modifies placental proteome and function, we performed untargeted proteomics (LC-MS/...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056380 | Pride
Obesity Placenta Mcm-complex Early pregnancy Insulin Oxygen Placenta-growth Dna-damage repair Insulin sensitivity Trophoblast 
ProteomicsComparative Proteomics of PairedVocal Fold and Oral Mucosa Fibroblasts
Injuries of the vocal folds frequently heal with scar formation, which can have lifelong detrimental impact on voice quality. Current treatments to prevent or resolve scars of the vocal fold mucosa are highly unsatisfactory. In contrast, the adjacent oral mucosa is mostly resistant to scarring. Thes...
ORGANISM(S): Ovis aries 
2017-01-23 | PXD005106 | Pride
Lamina propria Oral mucosa Wound healing Fibrosis Laryngology Scar Vocal folds Fibroblasts 
ProteomicsOptimized data analysis avoiding trypsin artefacts
Most bottom-up proteomics experiments share two features: The use of trypsin to digest proteins for mass spectrometry and the statistic driven matching of the measured peptide fragment spectra against protein database derived in silico generated spectra. While this extremely powerful approach in com...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-04-15 | PXD002726 | Pride
Autolysis protected trypsin Data base search 
ProteomicsInvestigation of hepatic stellate cell proteomics during activa-tion with fetal bovine serum
Hepatic stellate cells (HSCs) are the major driving factor in liver fibrosis. Upon liver inflammation caused by alcohol abuse and/or a fatty liver, HSCs transform from a quiescent- into a proliferating, fibrotic phenotype. We study this transformation termed “activation”, using state of the art TIMS...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD029121 | Pride
Human Proteomics Activation Fibrosis Liver Hepatic stellate cells 
ProteomicsComparative proteomics of common allergenic tree pollens of birch, alder and hazelComparative proteomics of common allergenic tree pollens of birch, alder and hazel
It is known that, in addition to known allergens, other proteins in pollen can aid the development of an immune response in allergenic individuals. The contribution of the “unknown” protein allergens becomes especially prominent in phylogenetically related species where, despite of high homology of ...
ORGANISM(S): Alnus glutinosa Corylus avellana Betula pendula 
2021-04-21 | PXD021133 | Pride
Birch Alder Proteomics Pollen Hazel 
ProteomicsEfficiency of acetate-based isopropanol synthesis in Escherichia coli W is controlled by ATP availability
Due to increasing ecological concerns, recombinant microbial production of biochemicals from sustainable carbon sources like acetate is rapidly gaining importance. However, for establishing successful large-scale production scenarios, a solid understanding of metabolic driving forces is required to ...
ORGANISM(S): Escherichia coli 
2024-10-17 | PXD047939 | Pride
Acetate Isopropanol Ecoli Bioingeneering Ecoli w 
ProteomicsProteomic analysis of vocal fold fibroblasts exposed to cigarette smoke extract
Reinke’s edema is a cigarette associated, benign, mostly bilateral lesion of the vocal folds leading to dysphonia and dyspnea. Until today information about pathophysiology is only scarce, treatment is only surgical. To explore the pathophysiology of Reinke’s edema, we exposed near primary human voc...
ORGANISM(S): Homo sapiens (Human) 
2019-08-06 | PXD010640 | Pride
Cigarette smoke extract Fibroblasts Proteomics 
ProteomicsProteome analysis of mixed fatty acid treated hepatocytes
How hepatocytes respond to a fatty acid stimulus is the topic of continuous research, since it is essential for our understanding of non-alcoholic fatty liver disease a pathology with a hard to detect onset, estimated to be present in a quarter of the adult human population. As advanced stages inclu...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030764 | Pride
Palmitic acid Hepg2 Oleic acid Myristic acid Nafld 
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