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ProteomicsIdentification of the Cfap206 interactome from mouse testis to identify its role in cilia function
Cfap206 was immunoprecipitated from mouse testis to identify the interactome of this protein for further functional studies.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-29 | PXD018554 | Pride
Mouse testis Cfap206 
ProteomicsUsher syndrome proteins ADGRV1 (USH2C) and CIB2 (USH1J) interact and share a common interactome containing TRiC/CCT-BBS chaperonins
The human Usher syndrome (USH) is the most common form of a sensory hereditary ciliopathy characterized by progressive vision and hearing loss. Mutations in the genes ADGRV1 and CIB2 have been associated with two distinct sub-types of USH, namely USH2C and USH1J. The proteins encoded by the two gene...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042629 | Pride
Usher syndrome Tap Interactome 
ProteomicsCiliary-associated extracellular vesicles modulate WNT signalling
Primary cilia are microtubule based sensory organelles important for receiving and processing cellular signals. Recent studies have shown that cilia also release extracellular vesicles (EVs) but little is known about their composition and function. Because EVs have been shown to exert various functi...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-19 | PXD020466 | Pride
Cilia Bbs Smev 
ProteomicsFAM183b interactome - The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice
A SF-TAP tagged FAM183b fusion protein was expressed in HEK293T cells. Protein complexes were purified by tandem affinity purification to identify the FAM183b-associated protein complex.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2018-10-08 | PXD009409 | Pride
Human Mouse Protein complex 
ProteomicsCFAP43 interactome mouse testis
CFAP43 along with its protein complex was purified from mouse testisby a CFAP43 specific antibody to identify the CFAP43-associated protein complex.
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD015425 | Pride
Mouse Protein complexes Interactome 
ProteomicsActivity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo
Objective DLL1 is a mammalian Notch ligand with essential functions during embryonic development. We tagged endogenous DLL1 in one homologous recombination step such that AcGFP-HA tagged DLL1 could be converted by Cre-mediated site-specific recombination into StrepFlag tagged DLL1. We anticipated th...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD024680 | Pride
Protein complexes Endogenous tagging 
ProteomicsThe protein complex of kinesin motor KIF1C and its hereditary spastic paraplegia associated mutant G102A
Regulated local translation, RNA transport and protein localization are critical for spatio-temporal gene expression in neurons. The localization of mRNA and subsequent local protein synthesis contribute to neuronal functions like synaptogenesis, synapse pruning, axon guidance, axonal regeneration a...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD037387 | Pride
Hereditary spastic paraplegia Kif1c Neuronal cells 
ProteomicsFAM183b interactome
A SF-TAP tagged FAM183b fusion protein was expressed in HEK293T cells. Protein complexes were purified by tandem affinity purification to identify the FAM183b-associated protein complex.
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD010108 | Pride
Human Mouse Protein complex 
ProteomicsCFAP161 interactome from mouse testis
Identification of the interactome of the ciliary protein CFAP161 from mouse testit to identify the molecular function of this protein
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022420 | Pride
Mouse testis Cfap206 
ProteomicsIdentification of RNA binding proteins that interact with AU-rich elements of Lif 3`UTR
Leukemia inhibitory factor (LIF) is an important endogenous factor for photoreceptor protection. Lif is known to be upregulated both in induced and inherited disease models of photoreceptor degeneration only in a subset of Muller cells. Since Lif is induced in Muller cells in response to photorecept...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-20 | PXD001463 | Pride
Ltq orbitrap velos Silac Rna-pulldown Maxquant 
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