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GenomicsIdentification of Myc and Max genomic targets in mouse embryonic stem cells.
Myc is a master transcription factor that has been demonstrated to be required for embryonic stem cell (ESC) pluripotency, self-renewal, and inhibition of differentiation. Although recent works identified several Myc-targets in ESC the list of Myc binding sites is largely incomplete due to the low s...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-48175 | biostudies-arrayexpress
ProteomicsComparative characterization of osteoclasts derived from murine bone marrow macrophages and RAW 264.7 cells using quantitative proteomics
Osteoclasts (OCs) are bone-resorbing cells differentiated from macrophage/monocyte precursors in response to M-CSF and RANKL. In vitro models are principally based on primary bone marrow macrophages, but RAW 264.7 cells are frequently used because they are widely available, easy to culture, and more...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-27 | PXD009610 | Pride
Proteomics Raw264.7 Osteoclast Bone marrow macrophages 
TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
UnknownSelenoprotein M is expressed during bone development.
Not available
S-EPMC4904744 | biostudies-literature
ProteomicsVCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
The mass spectrometry data were acquired using a Q Exactive HF mass spectrometer coupled with an UltiMate 3000 RSLCnano liquid chromatography system. Peptide samples were dissolved in a loading buffer, introduced via an autosampler, and separated on an analytical column (75 μm × 25 cm, C18, 1.9 μm, ...
ORGANISM(S): Homo Sapiens 
2024-09-10 | PXD055763 |
ProteomicsMulti-Omic analyses reveal aberrant differentiation trajectory with WNT1 Loss-of-Function in type XV osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a serious genetic bone disorder characterized by congenital low bone mass, deformity and frequent fractures. Type XV OI is a moderate to severe form of skeletal dysplasia caused by WNT1 mutations. In this cohort study from southern China, we summarized the clinical ph...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050841 | Pride
Human Bone Osteogenesis imperfecta 
ProteomicsA Novel Two-Step Proteome Extraction Protocol for Bone Tissue: Enhancing Low-Abundance Protein Detection and Multi-Omics Compatibility
Bone metabolism is a dynamic process involving osteoblasts, osteoclasts, and osteocytes, which maintain skeletal integrity through continuous remodelling. Disruptions in this homeostasis – caused by mineral or hormonal imbalances, systemic metabolic or inflammatory conditions, or genetic predisposit...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-13 | PXD056459 | Pride
Proteome extraction Rat Bone tissue Multi-omics Comparison 
ProteomicsGenome-centric resolution of novel microbial lineages in a Centrosaurus fossil bone from the Late Cretaceous of North America
Exceptional preservation of endogenous organics such as collagens and osteocytes has been frequently reported in Mesozoic dinosaur fossils. The persistence of soft tissue in Mesozoic fossil bones has been challenged because of the susceptibility of proteins to degradation and because bone porosity a...
ORGANISM(S): Euzebya tangerina Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11 Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14 
2020-05-27 | PXD015750 | Pride
Uncultured microbial lineages Centrosaurus fossil bone 
ProteomicsCompound Deletion of Thrombospondin-1 and -2 Results in a Skeletal Phenotype not Predicted by the Single Gene Knockouts
The trimeric thrombospondin homologs, TSP1 and TSP2, are both components of bone tissue and contribute in redundant and distinct ways to skeletal physiology. The functional effects of combined TSP1 and TSP2 deficiency remain to be elucidated. Here, we examined the spectrum of detergent soluble prot...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-26 | PXD020832 | Pride
Thrombospondins Bone Osteoblasts Osteoclasts 
ProteomicsExploring the molecular mechanism of bone metastasis in prostate cancer
This study focuses on bone metastasis of prostate cancer. By analyzing clinical samples and serum samples, it aims to reveal key molecular mechanisms and explore diagnostic and therapeutic targets. The specific goals include: First, identifying molecular markers related to bone metastasis, using hig...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074143 | Pride
Bone metastasis Prostate cancer 
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