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ProteomicsCombined proteomics and transcriptomics identifies carboxypeptidase B1 and NF-κB associated proteins as putative biomarkers of metastasis in low grade breast cancer
Current prognostic factors are insufficient for precise risk-discrimination in breast cancer patients with low grade breast tumors, which, in disagreement with theoretical prognosis, occasionally form early lymph node metastasis. To identify markers for this group of patients, we employed iTRAQ-2DLC...
ORGANISM(S): Homo sapiens (Human) 
2015-04-23 | PXD000029 | Pride
Mass spectrometry Cancer biology Carboxypeptidase-b1 Breast cancer Orbitrap ftms Low grade Gene expression Biomarkers Transcriptomics Itraq Metastasis Nf-b 
ProteomicsCreatine kinase B, a downstream effector of MYB, controls migration of osteosarcoma cells via regulation of N-cadherin
A study aimed at identification of proteins associated with CRISPR/Cas-induced depletion of creatine kinase B (CKB) in SAOS-LM5 metastatic osteosarcoma cell line using LC-MS/MS in data-independent acquisition (DIA)-parallel accumulation serial fragmentation (diaPASEF) mode. Here we prepared two KO c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD065263 | Pride
Pasef Cell migration Creatine kinase b Data independent acquisition Osteosarcoma 
ProteomicsTransgelin silencing induces different processes in differrent breast cancer cell lines
Transgelin is a protein which has been described as a marker of several cancers. Interestingly, the literature describes both up- and down-regulation of transgelin in the tumor in comparison with non-tumor tissue. The mechanisms of transgelin function in cancer are considerably unknown. Transgelin i...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD016316 | Pride
Transgelin  breast cancer  metastasis  migration  apoptosis  cytoskeleton 
ProteomicsA large-scale assay library for targeted protein quantification in renal cell carcinoma tissues
Generation of a new library of targeted mass spectrometry assays for accurate protein quantification in malignant and normal kidney tissue. Aliquots of primary tumor tissue lysates from 86 patients with initially localized renal cell carcinoma (RCC), 75 patients with metastatic RCC treated with suni...
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD028411 | Pride
Data independent acquisition Targeted proteomics Assay library Spectral library Renal cancer Selected reaction monitoring 
ProteomicsAnalysis of proteotype, cell growth and metabolic changes induced by caspase-9 inhibition in chondrogenic cells
Caspase-9 is the major apical caspase responsible for triggering the intrinsic apoptotic pathway. Our pilot study indicated that specific inhibition of caspase-9 caused microscopically evident alterations in appearance of the primary chondrogenic cultures which cannot be explained by decrease in apo...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-03 | PXD034025 | Pride
Metabolism Proteomics Ms3 Dia Chondrogenesis Diapasef Caspase-9 Micromass cultures Itraq 
ProteomicsA hybrid DDA/DIA-PASEF based assay library for a deep proteotyping of triple-negative breast cancer
Generation of a new library of targeted mass spectrometry assays for accurate protein quantification in triple negative breast cancer (TNBC) tissues. Primary tumor tissue lysates from 105 TNBC patients treated at Masaryk Memorial Cancer Institute (MMCI) in Brno, Czech Republic, were used to generate...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD047793 | Pride
Proteomics Mass spectrometry Data independent acquisition Assay library Triple-negative breast cancer 
ProteomicsTransgelin contributes to a poor response of metastatic renal cell carcinoma to sunitinib treatment
Renal cell carcinoma (RCC) represents about 2-3% of all cancers with over 400,000 new cases per year. Sunitinib, a vascular endothelial growth factor tyrosine kinase receptor inhibitor, has been used mainly for first-line treatment of metastatic clear-cell RCC with good or intermediate prognosis. Ho...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027065 | Pride
Mccrcc  sunitinib  resistance  dia-ms  transgelin 
ProteomicsProteomics identification and validation of desmocollin-1 and catechol-O-methyltransferase as proteins associated with breast cancer cell migration and metastasis
Biological treatment of many cancers currently targets membrane bound receptors located on a cell surface. To identify novel membrane proteins associated with migration and metastasis of breast cancer cells, we selected and characterized a more migrating subpopulation of MDA-MB-231 breast cancer cel...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD013162 | Pride
Breast cancer  mass spectrometry  metastasis  silac  transmembrane protein 
ProteomicsCatechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer cells. To delineate COMT role in metastasis of estrogen receptor dependent...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD033833 | Pride
Pulldown Breast cancer Comt Proteomics Dia 
ProteomicsDesmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously associated with lymph node metastasis of luminal A breast tumors and was found to increase metastatic potential of MCF7 cells in vitro. To delineate DSC1 role in breast cancer me...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041029 | Pride
Pulldown Breast cancer Proteomics Dia Dsc1 Metastasis 
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