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TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
UnknownThe blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Not available
S-EPMC7457506 | biostudies-literature
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models II
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools ...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD010664 | Pride
Alzheimer’s disease Proteomics Htau Ps1/app Mild-tbi Brain profiles Plasma biomarker 
TranscriptomicsRNAseq in Alzheimer's Disease patients
Human brain samples from healthy and advanced Alzheimer's diseased patients were subjected to RNA-seq analysis to monitor RNA level changes during AD progression. Human brain samples were obtained from the Mount Sinai Brain Bank; RNA was Trizol extracted, ribominus selected and submitted for high-th...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-53697 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Analysis of the Hippocampus from Six Inbred Strains of Mice Suggests Basis for Sex-Specific Susceptibility and Severity of Neurological Disorders
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioural disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease...
ORGANISM(S): Mus musculus 
2016-01-06 | E-GEOD-76567 | biostudies-arrayexpress
UnknownExtracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease.
Not available
S-EPMC12925786 | biostudies-literature
ProteomicsGlycomic and Proteomic changes in aging brain nigrostriatal pathway
This study identifies the age related changes in glycan receptors of heparan sulfate (HS) proteoglycan (receptor for rAAV2), and/or N-glycans with terminal galactose (receptor for rAAV9) and proteomics for receptors and co-receptors of adeno-associated virus in the nigro-striatal region of the brain...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-06-27 | PXD008990 | Pride
Hilic Mass spectrometry Reverse phase Gene therapy Aging nigro-striatal pathway Hilic-wax Lc-msms Label-free proteomics Heparan sulfate Adeno-associated virus N-glycans Proteomic Parkinson’s disease Glycomic 
TranscriptomicsAge-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex
The molecular basis of complex neuropsychiatric disorders most likely involves many genes. In recent years, specific genetic variations influencing risk for schizophrenia and other neuropsychiatric disorders have been reported. We have used custom DNA microarrays and qPCR to investigate the expressi...
ORGANISM(S): Homo sapiens 
2008-05-23 | E-GEOD-11546 | biostudies-arrayexpress
ProteomicsLarge-scale proteomics analysis of five brain regions from Parkinson’s disease patients with a GBA1 mutation
Despite being the second most common neurodegenerative disorder, little is known about Parkinson’s disease (PD) pathogenesis. A number of genetic factors predispose towards PD, among them mutations in GBA1, which encodes the lysosomal enzyme acid-β-glucosidase. We now perform non-targeted, mass spec...
ORGANISM(S): Homo sapiens (Human) 
2024-02-19 | PXD047134 | Pride
Α-synuclein Lysosomal storage disorders Parkinson’s disease Gaucher disease Proteomics. 
ProteomicsUnbiased proteomic analyses of plasma and brain tissue from TBI and AD mouse models
The relationship between repetitive mild traumatic brain injury (r-mTBI) and Alzheimer’s disease (AD) is well-recognized. However, the precise nature of how r-mTBI leads to or precipitates AD pathogenesis is currently not understood. Part A: Plasma biomarkers potentially provide non-invasive tools...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD010602 | Pride
Ad Hippocampus Tmt Plasma Cortex Tbi 
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